| The cardiovascular effects of bromocriptine in Parkinsonism. | |
| | |
MedLine Citation:
|
PMID: 22216496 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The cardiovascular effects of bromocriptine, a dopamine receptor agonist, were investigated in twenty-eight Parkinsonian patients. Bromocriptine caused a significant impairment of postural compensation with a fall in systolic pressure and an absence of the rise in diastolic pressure after standing for 1 min when patients taking active drug were compared to the same patients on placebo. The hypotensive effect persisted for at least 6 weeks of treatment. There was also a significant reduction in supine heart rate. One patient had marked falls in supine and erect blood pressure after a single oral dose of bromocriptine (2.5 mg) and a further patient developed paroxysmal atrial tachyarrhythmias. Both blood pressure and heart rate changes reversed spontaneously after stopping bromocriptine. It is proposed that dopaminergic mechanisms either in the central nervous system or the periphery contribute to cardiovascular regulation in man. |
| | |
Authors:
|
J K Greenacre; P F Teychenne; A Petrie; D B Calne; P N Leigh; J L Reid |
Related Documents
:
|
19691976 - Not every bulb is a rose: a functional comparison of bulb suction devices. 21878596 - Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more ... 22026536 - Impact of overweight and obesity in carotid intima-media thickness of portuguese adoles... 22231936 - Hypertension in type 1 diabetic patients-the influence of body composition and body mas... 16508586 - Dynamic testing with high-dose adrenocorticotrophic hormone does not improve lateraliza... 6202976 - Comparative haemodynamic effects of lidocaine, mexiletine, and disopyramide. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 3 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1976 Aug |
Date Detail:
|
Created Date: 2012-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 571-4 Citation Subset: IM |
Affiliation:
|
Departments of Medicine (Neurology) and Clinical Pharmacology, Royal Postgraduate Medical School, Du Cane Road, London W12 0HS. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A therapeutic audit at autopsy.
Next Document: CSF concentrations and serum protein binding of carbamazepine and carbamazepine-10,11-epoxide in epi...