Document Detail


The cardiovascular depression caused by bee venom in Sprague-Dawley rats associated with a decrease of developed pressure in the left ventricular and the ratio of ionized calcium/ionized magnesium.
MedLine Citation:
PMID:  18543385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bee venom (BV) has been used in Oriental medicine to treat inflammatory diseases, such as tendonitis, bursitis, and rheumatoid arthritis, despite the sensitivity of the victims and toxicity of the venom. This study examined the mechanisms for the effects of BV on the cardiovascular system in rats. The arterial pressure and heart rate (HR) were measured in anesthetized rats. In addition, the left ventricular development pressure (LVDP) and total magnesium efflux ([Mg]e) in isolated perfused hearts, the vascular tonic responses in the isolated aorta, and the blood ionic and biochemical changes were determined simultaneously. In the anesthetized rats, the mean arterial pressure, systolic pressure, and pulse pressure were reduced by BV in a dose-dependent manner, even though the HR was increased. BV had no effects on the relaxation of phenylephrine- or KCl-induced contraction of the aortic rings. In the isolated hearts, BV generated a reversible decrease in the LVDP and velocity with changes in pressure, which were accompanied by increases in the HR and [Mg]e. BV increased the plasma ionized and total magnesium concentrations, and decreased the total magnesium level in the red blood cells. The ratio of ionized calcium/ionized magnesium was also decreased by the BV treatment. BV caused a detectable increase in blood creatine kinase, glutamic oxaloacetic transaminase, and lactic dehydrogenase, as well as a decrease in the blood total protein albumin and globulin levels. These results suggest that BV induces cardiovascular depression by decreasing the cardiac pressure and increasing the ionized magnesium concentration in the blood.
Authors:
Hyung-Sub Kang; Shang-Jin Kim; Mun-Young Lee; Seol-Hee Jeon; Sung-Zoo Kim; Jin-Shang Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of Chinese medicine     Volume:  36     ISSN:  0192-415X     ISO Abbreviation:  Am. J. Chin. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901431     Medline TA:  Am J Chin Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  505-16     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, College of Veterinary Medicine, Bio-Safety Research Institute, Chonbuk National University, Center for the Healthcare Technology Development, Jeonju 561-756, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bee Venoms / pharmacology*
Blood Pressure / drug effects,  physiology
Calcium / metabolism*
Cardiovascular System / drug effects*,  metabolism,  physiopathology
Heart Rate / drug effects,  physiology
Magnesium / metabolism*
Male
Phenylephrine / pharmacology
Potassium Chloride / pharmacology
Rats
Rats, Sprague-Dawley
Vasoconstriction / drug effects,  physiology
Vasoconstrictor Agents / pharmacology
Vasodilation / drug effects,  physiology
Ventricular Function, Left / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Bee Venoms; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride

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