| The cardiovascular depression caused by bee venom in Sprague-Dawley rats associated with a decrease of developed pressure in the left ventricular and the ratio of ionized calcium/ionized magnesium. | |
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MedLine Citation:
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PMID: 18543385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bee venom (BV) has been used in Oriental medicine to treat inflammatory diseases, such as tendonitis, bursitis, and rheumatoid arthritis, despite the sensitivity of the victims and toxicity of the venom. This study examined the mechanisms for the effects of BV on the cardiovascular system in rats. The arterial pressure and heart rate (HR) were measured in anesthetized rats. In addition, the left ventricular development pressure (LVDP) and total magnesium efflux ([Mg]e) in isolated perfused hearts, the vascular tonic responses in the isolated aorta, and the blood ionic and biochemical changes were determined simultaneously. In the anesthetized rats, the mean arterial pressure, systolic pressure, and pulse pressure were reduced by BV in a dose-dependent manner, even though the HR was increased. BV had no effects on the relaxation of phenylephrine- or KCl-induced contraction of the aortic rings. In the isolated hearts, BV generated a reversible decrease in the LVDP and velocity with changes in pressure, which were accompanied by increases in the HR and [Mg]e. BV increased the plasma ionized and total magnesium concentrations, and decreased the total magnesium level in the red blood cells. The ratio of ionized calcium/ionized magnesium was also decreased by the BV treatment. BV caused a detectable increase in blood creatine kinase, glutamic oxaloacetic transaminase, and lactic dehydrogenase, as well as a decrease in the blood total protein albumin and globulin levels. These results suggest that BV induces cardiovascular depression by decreasing the cardiac pressure and increasing the ionized magnesium concentration in the blood. |
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Authors:
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Hyung-Sub Kang; Shang-Jin Kim; Mun-Young Lee; Seol-Hee Jeon; Sung-Zoo Kim; Jin-Shang Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of Chinese medicine Volume: 36 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 505-16 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, College of Veterinary Medicine, Bio-Safety Research Institute, Chonbuk National University, Center for the Healthcare Technology Development, Jeonju 561-756, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bee Venoms / pharmacology* Blood Pressure / drug effects, physiology Calcium / metabolism* Cardiovascular System / drug effects*, metabolism, physiopathology Heart Rate / drug effects, physiology Magnesium / metabolism* Male Phenylephrine / pharmacology Potassium Chloride / pharmacology Rats Rats, Sprague-Dawley Vasoconstriction / drug effects, physiology Vasoconstrictor Agents / pharmacology Vasodilation / drug effects, physiology Ventricular Function, Left / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Bee Venoms; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride |
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