| The cardiorespiratory effects of intrathecal xylazine in the conscious rabbit. | |
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MedLine Citation:
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PMID: 2319633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The alpha 2 agonist xylazine produced a dose-dependent decrease in mean arterial blood pressure in conscious rabbits when injected intrathecally (i.t.) through a cannula previously implanted under general anaesthesia. Intrathecal administration of 200 and 400 micrograms of xylazine produced a significant reduction in arterial blood pressure from control values (maximum depressions of 25% and 33%, respectively). There was little effect on cardiac output and arterial carbon-dioxide tension and no effect on respiratory rate, arterial oxygen tension and pulse rate. Intrathecal injection of 100 microliters of 0.9% saline had no effect. Intravenous (i.v.) tolazoline (0.5 mg/kg) abolished xylazine-induced hypotension (200 micrograms) in four rabbits. Contrast radiography revealed that 100 microliters of solution injected i.t. in anaesthetized rabbits spread distally over eight vertebral spaces. There was little rostral spread. It was concluded that xylazine-induced hypotension following i.t. injection was due to local activation of alpha 2 adrenoceptors present in the thoracic spinal cord. It is postulated that spinal alpha 2 adrenoceptors may play an important role in the hypotension recorded in animals after parenteral injection of xylazine. |
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Authors:
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A M Nolan; W Erhardt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary pharmacology and therapeutics Volume: 13 ISSN: 0140-7783 ISO Abbreviation: J. Vet. Pharmacol. Ther. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-05-10 Completed Date: 1990-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910920 Medline TA: J Vet Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM; S |
Affiliation:
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Institute of Experimental Surgery, Technical University, Munich, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Monitoring, Transcutaneous / veterinary Blood Pressure / drug effects* Cardiac Output / drug effects* Hypotension / chemically induced Injections, Spinal / veterinary Rabbits* Respiration / drug effects* Thiazines / pharmacology* Tolazoline / pharmacology Xylazine / administration & dosage, antagonists & inhibitors, pharmacology* Yohimbine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Thiazines; 146-48-5/Yohimbine; 59-98-3/Tolazoline; 7361-61-7/Xylazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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