Document Detail

The cardiorespiratory effects of intrathecal xylazine in the conscious rabbit.
MedLine Citation:
PMID:  2319633     Owner:  NLM     Status:  MEDLINE    
The alpha 2 agonist xylazine produced a dose-dependent decrease in mean arterial blood pressure in conscious rabbits when injected intrathecally (i.t.) through a cannula previously implanted under general anaesthesia. Intrathecal administration of 200 and 400 micrograms of xylazine produced a significant reduction in arterial blood pressure from control values (maximum depressions of 25% and 33%, respectively). There was little effect on cardiac output and arterial carbon-dioxide tension and no effect on respiratory rate, arterial oxygen tension and pulse rate. Intrathecal injection of 100 microliters of 0.9% saline had no effect. Intravenous (i.v.) tolazoline (0.5 mg/kg) abolished xylazine-induced hypotension (200 micrograms) in four rabbits. Contrast radiography revealed that 100 microliters of solution injected i.t. in anaesthetized rabbits spread distally over eight vertebral spaces. There was little rostral spread. It was concluded that xylazine-induced hypotension following i.t. injection was due to local activation of alpha 2 adrenoceptors present in the thoracic spinal cord. It is postulated that spinal alpha 2 adrenoceptors may play an important role in the hypotension recorded in animals after parenteral injection of xylazine.
A M Nolan; W Erhardt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  13     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-10     Completed Date:  1990-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM; S    
Institute of Experimental Surgery, Technical University, Munich, FRG.
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MeSH Terms
Blood Gas Monitoring, Transcutaneous / veterinary
Blood Pressure / drug effects*
Cardiac Output / drug effects*
Hypotension / chemically induced
Injections, Spinal / veterinary
Respiration / drug effects*
Thiazines / pharmacology*
Tolazoline / pharmacology
Xylazine / administration & dosage,  antagonists & inhibitors,  pharmacology*
Yohimbine / pharmacology
Reg. No./Substance:
0/Thiazines; 146-48-5/Yohimbine; 59-98-3/Tolazoline; 7361-61-7/Xylazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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