| The cardiorenal syndrome in diabetes mellitus. | |
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MedLine Citation:
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PMID: 20599286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiorenal syndrome in patients with diabetes mellitus represents a systemic condition that affects both the cardiovascular and renal systems. Diabetes is a well established risk factor for cardiovascular disease (CVD), and a significant proportion of diabetic patients go on to develop clinically significant nephropathy. In the diabetic state the kidney is involved by progressive sclerosis/fibrosis and proteinuria, due most likely to overactivity of the transforming growth factor-beta system and, to some extent, the vascular endothelial growth factor system, respectively. The pathogenesis of CVD in diabetes is multifactorial, involving hemodynamic forces, humoral/metabolic factors, and oxidative stress. Additionally, it has been suggested that endothelial dysfunction may lead to simultaneous development and progression of renal and cardiac pathology in diabetes. The risk of microvascular complications can be reduced by intensive glycemic control in patients with type 1 and type 2 diabetes mellitus whereas benefit to the cardiovascular system is less clear. However, intensified intervention involving other CVD risk factors like hypertension and dyslepidemia and interception of the rennin-angiotensin-aldosterone system in patients with type 2 diabetes have been shown to be associated with significant reduction in the risk for renal disease progression that was paralleled by a significant reduction in cardiovascular disease burden. |
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Authors:
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Hussein H Karnib; Fuad N Ziyadeh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 89 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 201-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Physiology and Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. hk19@aub.edu.lb |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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etiology*,
pathology Diabetes Complications / pathology, physiopathology* Diabetes Mellitus / pathology, physiopathology* Female Humans Kidney Diseases / etiology*, pathology Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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