Document Detail

The cardioprotective actions of iloprost in myocardial ischemia of the rabbit can be separated from its vasodilatory effects mediated by KATP(+)-channel opening.
MedLine Citation:
PMID:  7536387     Owner:  NLM     Status:  MEDLINE    
The modification of cardioprotective actions of iloprost by K(+)-channel blockade was studied in ischemic rabbit hearts. Glibenclamide, a blocker of ATP-dependent K(+)-channels, prevented coronary vasodilation mediated by the prostacyclin mimetic iloprost. In contrast, the cardioprotective effects of iloprost which were determined from prevention of ischemia induced rise in left ventricular enddiastolic pressure and loss of cytosolic troponin T in hearts made globally ischemic for two hours were not affected by glibenclamide. It is concluded that the cardioprotective action of iloprost can be separated from ist coronary vasodilator effect mediated by opening KATP(+)-channels.
A Vesper; K Schrör
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions. Supplements     Volume:  45     ISSN:  0379-0363     ISO Abbreviation:  Agents Actions Suppl.     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7801014     Medline TA:  Agents Actions Suppl     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
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MeSH Terms
Adenosine Triphosphate / metabolism*
Glyburide / pharmacology
Heart / drug effects,  physiopathology
Iloprost / pharmacology*
Myocardial Ischemia / metabolism,  prevention & control*
Potassium Channel Blockers*
Potassium Channels / metabolism
Vasodilation / drug effects*
Reg. No./Substance:
0/Potassium Channel Blockers; 0/Potassium Channels; 10238-21-8/Glyburide; 56-65-5/Adenosine Triphosphate; 78919-13-8/Iloprost

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