| The cardioprotective actions of iloprost in myocardial ischemia of the rabbit can be separated from its vasodilatory effects mediated by KATP(+)-channel opening. | |
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MedLine Citation:
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PMID: 7536387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The modification of cardioprotective actions of iloprost by K(+)-channel blockade was studied in ischemic rabbit hearts. Glibenclamide, a blocker of ATP-dependent K(+)-channels, prevented coronary vasodilation mediated by the prostacyclin mimetic iloprost. In contrast, the cardioprotective effects of iloprost which were determined from prevention of ischemia induced rise in left ventricular enddiastolic pressure and loss of cytosolic troponin T in hearts made globally ischemic for two hours were not affected by glibenclamide. It is concluded that the cardioprotective action of iloprost can be separated from ist coronary vasodilator effect mediated by opening KATP(+)-channels. |
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Authors:
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A Vesper; K Schrör |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions. Supplements Volume: 45 ISSN: 0379-0363 ISO Abbreviation: Agents Actions Suppl. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-05-18 Completed Date: 1995-05-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7801014 Medline TA: Agents Actions Suppl Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 93-9 Citation Subset: IM |
Affiliation:
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Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism* Animals Glyburide / pharmacology Heart / drug effects, physiopathology Iloprost / pharmacology* Myocardial Ischemia / metabolism, prevention & control* Perfusion Potassium Channel Blockers* Potassium Channels / metabolism Rabbits Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channel Blockers; 0/Potassium Channels; 10238-21-8/Glyburide; 56-65-5/Adenosine Triphosphate; 78919-13-8/Iloprost |
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