Document Detail


The cardio-renal-anaemia syndrome predicts survival in peritoneally dialyzed patients.
MedLine Citation:
PMID:  22371797     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Anaemia is one of the arms of the cardio-renal-anaemia syndrome (CRA) in chronic kidney disease (CKD) patients. The correction of anaemia was effective in the amelioration of both cardiac and renal failure. We studied the relationship between the severity of CRA syndrome in peritoneally dialyzed patients and their survival probability.
MATERIAL AND METHODS: Fifty-six patients on peritoneal dialysis were followed for 1 year. Definition of the severity of the CRA in dialysis patients: cardiac arm - NYHA class I-IV = 1-4 points, renal arm - non-diabetic patients age < 65 =1 point, non-diabetic patients age>65 = 2 points, diabetic patients age < 65 = 3 points, diabetic patients age>65 = 4 points, anaemia arm - Hb 11-13 g/dl (male), 11-12 g/dl (female) = 1 point, Hb 10-11 g/dl = 2 points, Hb 9-10 g/dl = 3 points, Hb < 9 g/dl = 4 points. The severity score = cardiac + renal + anaemia arms score divided by 3 (maximum 4 points).
RESULTS: A total of 10/56 patients (18%) died during the study. The median value for the severity score of the whole group was 1.69. In Kaplan-Meier analysis CRA severity score was strongly associated with mortality (p < 0.001). It also correlated with albumin, CRP, erythropoietin treatment, Hb and fasting glucose. In the multivariate regression analysis age, Hb, albumin, and presence of diabetes remained significant predictors of death.
CONCLUSIONS: The severity score of CRA syndrome in peritoneally dialyzed patients is an independent and very significant predictor of death. The patients with a high severity score had more hypoalbuminaemia, higher inflammation markers and higher prevalence of diabetes and chronic heart failure. Cardio-renal-anaemia syndrome severity scoring as defined by us could be an easy tool to predict outcome of dialysis patients.
Authors:
Jolanta Malyszko; Edyta Zbroch; Jacek Malyszko; Michal Mysliwiec; Adrian Iaina
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Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Archives of medical science : AMS     Volume:  6     ISSN:  1896-9151     ISO Abbreviation:  Arch Med Sci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101258257     Medline TA:  Arch Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  -    
Affiliation:
Department of Nephrology and Transplantology, Medical University, Bialystok, Poland.
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