Document Detail

The cardiac endothelium: functional morphology, development, and physiology.
MedLine Citation:
PMID:  8970576     Owner:  NLM     Status:  MEDLINE    
Cardiac endothelial cells, regardless of whether they are from endocardial or from coronary (micro)vascular origin, directly modulate performance of the subjacent cardiomyocytes, resulting in control of the onset of ventricular relaxation and rapid filling of the heart. This review summarizes major features of the morphology, embryology, and comparative physiology of cardiac endothelial cells as well as the experimental observations on how cardiac endothelial cells affect the mechanical performance of the heart. As for the underlying mechanisms of the interaction between cardiac endothelial cells and cardiomyocytes, two working hypotheses have been postulated over the past years; (1) interaction mediated through a trans-endothelial physicochemical gradient for various ions (active blood-heart barrier), and (2) interaction mediated through the release by the cardiac endothelial cells of various cardioactive substances, eg, nitric oxide, endothelin, and prostacyclin. These two mechanisms may act in concert or in parallel.
D L Brutsaert; G W De Keulenaer; P Fransen; P Mohan; G L Kaluza; L J Andries; J L Rouleau; S U Sys
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  39     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-01-15     Completed Date:  1997-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-62     Citation Subset:  AIM; IM    
Laboratory of Human Physiology and Pathophysiology, Antwerp University, Belgium.
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MeSH Terms
Cell Communication
Coronary Vessels / cytology*,  embryology,  physiology
Endocardium / cytology*,  embryology,  physiology
Endothelium / cytology,  embryology,  physiology
Endothelium, Vascular / cytology*,  embryology,  physiology
Myocardial Contraction
Nitric Oxide / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide

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