Document Detail

The cardiac endothelium: cardioactive mediators.
MedLine Citation:
PMID:  8970577     Owner:  NLM     Status:  MEDLINE    
Endothelial cells within the heart release a number of substances that modulate myocardial contractile function. These agents include nitric oxide, endothelin, prostanoids, adenylpurines, and other substances that have so far been characterized only in bioassay studies. A notable feature of many of these agents is that they influence contractile behavior predominantly by modifying cardiac myofilament properties rather than altering cytosolic Ca2+ transients. A consequence of this subcellular action is often a disproportionate effect on myocardial relaxation and diastolic tone. The paracrine modulation of cardiac myocyte function by endothelial cell factors is likely to be an important mechanism contributing to the overall regulation of cardiac contractile function, both physiologically and in pathological states.
A M Shah; R M Grocott-Mason; C B Pepper; A Mebazaa; A H Henderson; M J Lewis; W J Paulus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  39     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-01-15     Completed Date:  1997-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-84     Citation Subset:  AIM; IM    
Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom.
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MeSH Terms
Coronary Vessels / physiology*
Endocardium / physiology*
Endothelin-1 / physiology
Endothelium / physiology
Endothelium, Vascular / physiology*
Myocardial Contraction / physiology
Nitric Oxide / physiology
Prostaglandins / physiology
Reg. No./Substance:
0/Endothelin-1; 0/Prostaglandins; 10102-43-9/Nitric Oxide

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