Document Detail

The cardiac effects of therapeutic plasma concentrations of imipramine.
MedLine Citation:
PMID:  645944     Owner:  NLM     Status:  MEDLINE    
The authors studied the effects of imipramine hydrochloride at plasma concentrations associated with antidepressant activity in seven patients hospitalized for severe depressive illness. They found that the drug usually produced prolongation of intraventricular cardiac conduction. Although this was generally well tolerated, the authors suggest that patients with preexisting conduction system disease may be at increased risk when taking tricyclic antidepressants. They feel that the orthostatic hypotension seen in all seven patients represents a potentially serious problem with tricyclic antidepressants. They discuss the antiarrhythmic properties associated with imipramine and significant interactions between imipramine and drugs taken by patients with cardiovascular disease.
S J Kantor; A H Glassman; J T Bigger; J M Perel; E V Giardina
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  135     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  534-8     Citation Subset:  AIM; IM    
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MeSH Terms
Depression / drug therapy*
Heart / drug effects*
Heart Conduction System / drug effects
Hypotension, Orthostatic / chemically induced
Imipramine / adverse effects,  blood*,  therapeutic use
Middle Aged
Reg. No./Substance:

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