| The cardiac effects of therapeutic plasma concentrations of imipramine. | |
MedLine Citation:
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PMID: 645944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors studied the effects of imipramine hydrochloride at plasma concentrations associated with antidepressant activity in seven patients hospitalized for severe depressive illness. They found that the drug usually produced prolongation of intraventricular cardiac conduction. Although this was generally well tolerated, the authors suggest that patients with preexisting conduction system disease may be at increased risk when taking tricyclic antidepressants. They feel that the orthostatic hypotension seen in all seven patients represents a potentially serious problem with tricyclic antidepressants. They discuss the antiarrhythmic properties associated with imipramine and significant interactions between imipramine and drugs taken by patients with cardiovascular disease. |
Authors:
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S J Kantor; A H Glassman; J T Bigger; J M Perel; E V Giardina |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of psychiatry Volume: 135 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-06-12 Completed Date: 1978-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 534-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Depression / drug therapy* Electrocardiography Heart / drug effects* Heart Conduction System / drug effects Humans Hypotension, Orthostatic / chemically induced Imipramine / adverse effects, blood*, therapeutic use Middle Aged |
| Chemical | |
Reg. No./Substance:
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50-49-7/Imipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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