Document Detail

The cardiac cycle and the physiologic basis of left ventricular contraction, ejection, relaxation, and filling.
MedLine Citation:
PMID:  18313620     Owner:  NLM     Status:  MEDLINE    
Heart failure is defined as the pathologic state in which the heart is unable to pump blood at a rate required by the metabolizing tissues or can do so only with an elevated filling pressure. Heart failure in adults most frequently results from the inability of the left ventricle to fill (diastolic performance) or eject (systolic performance) blood. The severity of heart failure and its prognosis are more closely related to the degree of diastolic filling abnormalities than the ejection fraction, which underscores the importance of understanding the mechanisms of diastolic abnormalities in heart failure.
Hidekatsu Fukuta; William C Little
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Heart failure clinics     Volume:  4     ISSN:  1551-7136     ISO Abbreviation:  Heart Fail Clin     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-03-25     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  101231934     Medline TA:  Heart Fail Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
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MeSH Terms
Exercise Tolerance
Heart Failure / physiopathology*
Myocardial Contraction
Stroke Volume / physiology*
Ventricular Function*
Grant Support
R01 AA012335/AA/NIAAA NIH HHS; R01 AA012335-05/AA/NIAAA NIH HHS; R01 HL053541-04/HL/NHLBI NIH HHS; R01 HL074318/HL/NHLBI NIH HHS; R01 HL074318-04/HL/NHLBI NIH HHS; R29 HL045258/HL/NHLBI NIH HHS; R29 HL045258-05/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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