Document Detail

The cardiac contraction cycle: Is Ca2+ going local?
MedLine Citation:
PMID:  19299570     Owner:  NLM     Status:  Publisher    
The myriad of intracellular signalling pathways involving intracellular Ca(2+) means Ca(2+) plays a role in everything from cellular metabolism to cell death. In heart muscle Ca(2+) is primarily known for its role in cellular contraction. Regulation of cardiac muscle contractility is achieved through modulation of the spatio-temporal nature of intracellular Ca(2+) signals, operating in areas of restricted diffusion or microdomains, close to Ca(2+) release sites. This Viewpoint article briefly integrates experimental evidence in support of this concept. Key words: Heart Muscle, Cardiac, Calcium, Microdomain.
Mark Richard Fowler; Godfrey L Smith
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-3-19
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of GLasgow.
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