Document Detail


The carcinogenicity of 1-methyl-3(p-bromophenyl)-1-nitrosourea (Br-MPNU).
MedLine Citation:
PMID:  6625867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In long-term experiments with Hooded rats the carcinogenic potential of 1-methyl-3(p-bromophenyl)-1-nitrosourea (Br-MPNU) could be demonstrated for the first time. Br-MPNU is formed also endogenously after combined administration of 1-methyl-3(p-bromophenyl)-urea (Br-MPU) and sodium nitrite. After repeated intragastric administration of 0.33 mmol Br-MPU and 0.73 mmol NaNO2 per kg b.w. papillomas and carcinomas of the forestomach developed in 83%. After repeated administration of 0.28 mmol Br-MPNU per kg b.w. these neoplasms were observed in 88%. The comparison of results obtained in similar experiments with 1-methyl-3-phenyl-1-nitrosourea shows that bromine substitution led to a reduction of the carcinogenic activity. The present paper is part of a complex program studying the interrelationships between structure, physico-chemical properties, mutagenicity and carcinogenicity of nitrosoureas.
Authors:
R Warzok; J Martin; J Mendel; R Thust; H Schwarz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archiv für Geschwulstforschung     Volume:  53     ISSN:  0003-911X     ISO Abbreviation:  Arch. Geschwulstforsch.     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372411     Medline TA:  Arch Geschwulstforsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Carcinogens / toxicity*
Drug Interactions
Female
Male
Neoplasms, Experimental / chemically induced*
Nitrosourea Compounds / administration & dosage,  toxicity*
Phenylurea Compounds / toxicity
Rats
Rats, Inbred Strains
Sodium Nitrite / toxicity
Stomach Neoplasms / chemically induced
Time Factors
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Nitrosourea Compounds; 0/Phenylurea Compounds; 20680-07-3/1-methyl-3-(4-bromophenyl)urea; 23139-02-8/1-methyl-3-(4-bromophenyl)-1-nitrosourea; 7632-00-0/Sodium Nitrite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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