Document Detail

The carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) is a potential serum marker of ongoing liver fibrosis.
MedLine Citation:
PMID:  8740582     Owner:  NLM     Status:  MEDLINE    
We report for the first time the measurement of the serum concentration of the carboxy-terminal cross-linked telopeptide of type I collagen in patients with various liver diseases. This breakdown product of type I collagen, which is the major collagen type found in fibrotic liver, was measured by a radioimmunoassay in the serum of 149 patients with various liver diseases and in 67 controls. Its concentration is significantly elevated (P < 0.05) above reference intervals in sera from patients with liver diseases, except in patients with chronic active hepatitis of unknown origin and in patients with acute hepatitis A. In the 143 patients with liver fibrosis, the serum level of the carboxy-terminal telopeptide of type I collagen is correlated with the extent of fibrosis, as assessed by a histological scoring system (r = 0.3899, P < 0.0001), but not with inflammation and necrosis.
S Ricard-Blum; P Chossegros; S Guerret; C Trepo; J A Grimaud; M Chevallier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  248     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-01-15     Completed Date:  1997-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Institut Pasteur de Lyon, CNRS URA 1459 Pathologie des Fibroses, Lyon, France.
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MeSH Terms
Biological Markers / blood*
Collagen / blood*
Collagen Type I
Cross-Linking Reagents
Hepatitis A / blood
Hepatitis, Chronic / blood
Liver Cirrhosis / blood*,  pathology,  virology
Liver Diseases, Alcoholic / blood
Liver Neoplasms / blood
Middle Aged
Peptides / blood*
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Cross-Linking Reagents; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 9007-34-5/Collagen

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