Document Detail


A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans.
MedLine Citation:
PMID:  18524954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homeostasis of internal carbon dioxide (CO2) and oxygen (O2) levels is fundamental to all animals. Here we examine the CO2 response of the nematode Caenorhabditis elegans. This species inhabits rotting material, which typically has a broad CO2 concentration range. We show that well fed C. elegans avoid CO2 levels above 0.5%. Animals can respond to both absolute CO2 concentrations and changes in CO2 levels within seconds. Responses to CO2 do not reflect avoidance of acid pH but appear to define a new sensory response. Sensation of CO2 is promoted by the cGMP-gated ion channel subunits TAX-2 and TAX-4, but other pathways are also important. Robust CO2 avoidance in well fed animals requires inhibition of the DAF-16 forkhead transcription factor by the insulin-like receptor DAF-2. Starvation, which activates DAF-16, strongly suppresses CO2 avoidance. Exposure to hypoxia (<1% O2) also suppresses CO2 avoidance via activation of the hypoxia-inducible transcription factor HIF-1. The npr-1 215V allele of the naturally polymorphic neuropeptide receptor npr-1, besides inhibiting avoidance of high ambient O2 in feeding C. elegans, also promotes avoidance of high CO2. C. elegans integrates competing O2 and CO2 sensory inputs so that one response dominates. Food and allelic variation at NPR-1 regulate which response prevails. Our results suggest that multiple sensory inputs are coordinated by C. elegans to generate different coherent foraging strategies.
Authors:
Andrew Jonathan Bretscher; Karl Emanuel Busch; Mario de Bono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-11     Completed Date:  2008-06-27     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8044-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaerobiosis / drug effects
Animals
Avoidance Learning / drug effects*
Caenorhabditis elegans / drug effects*,  physiology*
Caenorhabditis elegans Proteins / metabolism
Carbon Dioxide / pharmacology*
Cyclic GMP / metabolism
Feeding Behavior / drug effects*
Food Deprivation
Genotype
Hydrogen-Ion Concentration
Insulin / metabolism
Ion Channel Gating / drug effects
Motor Activity / drug effects
Oxygen / metabolism*
Receptors, Neuropeptide Y / metabolism
Signal Transduction / drug effects
Grant Support
ID/Acronym/Agency:
MC_U105178786//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Insulin; 0/NPR-1 protein, C elegans; 0/Receptors, Neuropeptide Y; 142M471B3J/Carbon Dioxide; H2D2X058MU/Cyclic GMP; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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