Document Detail

A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans.
MedLine Citation:
PMID:  18524954     Owner:  NLM     Status:  MEDLINE    
Homeostasis of internal carbon dioxide (CO2) and oxygen (O2) levels is fundamental to all animals. Here we examine the CO2 response of the nematode Caenorhabditis elegans. This species inhabits rotting material, which typically has a broad CO2 concentration range. We show that well fed C. elegans avoid CO2 levels above 0.5%. Animals can respond to both absolute CO2 concentrations and changes in CO2 levels within seconds. Responses to CO2 do not reflect avoidance of acid pH but appear to define a new sensory response. Sensation of CO2 is promoted by the cGMP-gated ion channel subunits TAX-2 and TAX-4, but other pathways are also important. Robust CO2 avoidance in well fed animals requires inhibition of the DAF-16 forkhead transcription factor by the insulin-like receptor DAF-2. Starvation, which activates DAF-16, strongly suppresses CO2 avoidance. Exposure to hypoxia (<1% O2) also suppresses CO2 avoidance via activation of the hypoxia-inducible transcription factor HIF-1. The npr-1 215V allele of the naturally polymorphic neuropeptide receptor npr-1, besides inhibiting avoidance of high ambient O2 in feeding C. elegans, also promotes avoidance of high CO2. C. elegans integrates competing O2 and CO2 sensory inputs so that one response dominates. Food and allelic variation at NPR-1 regulate which response prevails. Our results suggest that multiple sensory inputs are coordinated by C. elegans to generate different coherent foraging strategies.
Andrew Jonathan Bretscher; Karl Emanuel Busch; Mario de Bono
Related Documents :
2355824 - Ventilatory threshold and maximal oxygen uptake during cycling and running in triathletes.
21844274 - Comparison of environmental and egg microbiology associated with conventional and free-...
9854844 - Wild rabbit host and some parasites show trophic-level relationships for delta 13c and ...
11537384 - Closed and continuous algae cultivation system for food production and gas exchange in ...
23129604 - Municipal solid waste management for total resource recycling: a case study on haulien ...
10735744 - Nutrient flows for poultry production in the netherlands.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-11     Completed Date:  2008-06-27     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8044-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anaerobiosis / drug effects
Avoidance Learning / drug effects*
Caenorhabditis elegans / drug effects*,  physiology*
Caenorhabditis elegans Proteins / metabolism
Carbon Dioxide / pharmacology*
Cyclic GMP / metabolism
Feeding Behavior / drug effects*
Food Deprivation
Hydrogen-Ion Concentration
Insulin / metabolism
Ion Channel Gating / drug effects
Motor Activity / drug effects
Oxygen / metabolism*
Receptors, Neuropeptide Y / metabolism
Signal Transduction / drug effects
Grant Support
MC_U105178786//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Insulin; 0/NPR-1 protein, C elegans; 0/Receptors, Neuropeptide Y; 142M471B3J/Carbon Dioxide; H2D2X058MU/Cyclic GMP; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The tactile integration of local motion cues is analogous to its visual counterpart.
Next Document:  Acute carbon dioxide avoidance in Caenorhabditis elegans.