Document Detail

The caprine oxyhemoglobin dissociation curve.
MedLine Citation:
PMID:  15946714     Owner:  NLM     Status:  MEDLINE    
The caprine oxyhemoglobin dissociation curve has not been previously defined. Blood from 10 healthy goats was equilibrated in a tonometer with calibrated gas mixtures of oxygen at concentrations of 95%, 21%, 13%, 12%, 10%, 9%, 8%, 5%, 4%, and 2.5% , 5% carbon dioxide, balance nitrogen. The pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), total hemoglobin, oxyhemoglobin saturation, carboxyhemoglobin, methemoglobin, and oxygen content were measured. The PO2/oxyhemoglobin and the PO2/oxygen content relationships were graphed with curve-fitting software and a formula for calculating oxyhemoglobin from PO2 was generated. The maximum oxygen content per gram of hemoglobin was 1.29 ml of oxygen per gram of hemoglobin. The PO2 at which hemoglobin was 50% saturated (P50) from the PO2/oxyhemoglobin relationship was 28.6+/-1.5 mmHg and that from the PO2/oxygen content relationships was 29.1+/-1.6 mmHg. The Hill coefficient for the PO2/oxyhemoglobin data was 3.0+/-0.4.
Steve C Haskins; Marlis L Rezende
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Publication Detail:
Type:  Journal Article     Date:  2005-06-08
Journal Detail:
Title:  Research in veterinary science     Volume:  80     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2006-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California, Davis, CA 95616-8745, USA.
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MeSH Terms
Goats / blood*
Hydrogen-Ion Concentration
Oxygen / analysis,  metabolism
Oxyhemoglobins / metabolism*
Partial Pressure
Reg. No./Substance:
0/Oxyhemoglobins; 7782-44-7/Oxygen

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