Document Detail

The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food.
MedLine Citation:
PMID:  17462824     Owner:  NLM     Status:  MEDLINE    
The assumption of a novel high palatable food (a candied cherry) occurs concomitantly with an increase in the concentration of extra-cellular dopamine and its main metabolite 3,4-dihydroxy-phenylacetic acid (DOPAC) by about 45% in the dialysate obtained by intracerebral microdialysis from the shell of the nucleus accumbens of male rats. Such increase was reversed by SR 141716A (Rimonabant), a selective cannabinoid CB1 receptor antagonist (0.3 mg/kg i.p. and 1 mg/kg i.p.), which also reduces the assumption of the high palatable food, when given 15 min before exposure to the candied cherry. SR 141716A effects on extracellular dopamine and DOPAC were prevented by WIN 55,212-2 (0.3 mg/kg i.p.) or HU 210 (0.1 mg/kg i.p.) given 15 min before SR 141716A. The present results show for the first time that SR 141716A reduces the increase in extra-cellular dopamine induced by a novel high palatable food in the nucleus accumbens. This confirms that cannabinoid CB1 receptors play a key role in food intake and/or appetite and suggests that the mesolimbic dopaminergic system is involved at least in part, in the effects of cannabinoid receptor agonists and antagonists on food intake and/or appetite.
Tiziana Melis; Salvatora Succu; Fabrizio Sanna; Antonio Boi; Antonio Argiolas; Maria Rosaria Melis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-08
Journal Detail:
Title:  Neuroscience letters     Volume:  419     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-09-28     Revised Date:  2007-10-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Bernard B. Brodie Department of Neuroscience, University of Cagliari, 09042 Monserrato, Cagliari, Italy.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Appetite Regulation / physiology*
Dopamine / metabolism*
Eating / physiology
Extracellular Fluid / chemistry
Nucleus Accumbens / drug effects*,  metabolism
Piperidines / pharmacology*
Pyrazoles / pharmacology*
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 / agonists,  antagonists & inhibitors,  drug effects*
Reg. No./Substance:
0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 158681-13-1/rimonabant

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