Document Detail


The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential.
MedLine Citation:
PMID:  10341359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of carboxylic acid metabolites of the cannabinoids (CBs) dates back more than three decades. Their lack of psychotropic activity was noted early on, and this resulted in a total absence of further research on their possible role in the actions of the CBs. More recent studies have revealed that the acids possess both analgesic and anti-inflammatory properties and may contribute to the actions of the parent drug. A synthetic analog showed similar actions at considerably lower doses. In this review, a brief survey of the extensive literature on metabolism of delta 9-tetrahydrocannabinol to the acids is presented, while more emphasis is given to the recent findings on the biological actions of this class of CBs. A possible mechanism involving effects on eicosanoids for some of these actions is also suggested. Finally, an analogy with a putative metabolite of anandamide, an endogenous CB, is discussed.
Authors:
S H Burstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  82     ISSN:  0163-7258     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-20     Completed Date:  1999-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01655-0103, USA.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / therapeutic use*
Animals
Anti-Inflammatory Agents / therapeutic use*
Arachidonic Acids / therapeutic use*
Cannabinoids / metabolism,  therapeutic use*
Humans
Polyunsaturated Alkamides
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
DA09017/DA/NIDA NIH HHS; DA09439/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Arachidonic Acids; 0/Cannabinoids; 0/Polyunsaturated Alkamides; 94421-68-8/anandamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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