Document Detail

The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential.
MedLine Citation:
PMID:  10341359     Owner:  NLM     Status:  MEDLINE    
The discovery of carboxylic acid metabolites of the cannabinoids (CBs) dates back more than three decades. Their lack of psychotropic activity was noted early on, and this resulted in a total absence of further research on their possible role in the actions of the CBs. More recent studies have revealed that the acids possess both analgesic and anti-inflammatory properties and may contribute to the actions of the parent drug. A synthetic analog showed similar actions at considerably lower doses. In this review, a brief survey of the extensive literature on metabolism of delta 9-tetrahydrocannabinol to the acids is presented, while more emphasis is given to the recent findings on the biological actions of this class of CBs. A possible mechanism involving effects on eicosanoids for some of these actions is also suggested. Finally, an analogy with a putative metabolite of anandamide, an endogenous CB, is discussed.
S H Burstein
Related Documents :
17768049 - Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans ...
17123759 - Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from...
10200579 - Activation of a low ph-dependent nuclease by apoptotic agents.
6732359 - Analgesic activities of amphetamine isomers.
3975919 - Quantitating exposure to chemical carcinogens: in vivo alkylation of hemoglobin by benz...
19154809 - A detailed investigation for determination of tannic acid by anodic stripping voltammet...
22063409 - Comparison of ascorbic acid and sodium erythorbate: effects on the 24h display colour o...
21390779 - Generation of labeled probes by pcr.
1682459 - Pharmacokinetics of valproic acid in guinea-pigs with biliary abnormality.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  82     ISSN:  0163-7258     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-20     Completed Date:  1999-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01655-0103, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analgesics / therapeutic use*
Anti-Inflammatory Agents / therapeutic use*
Arachidonic Acids / therapeutic use*
Cannabinoids / metabolism,  therapeutic use*
Polyunsaturated Alkamides
Structure-Activity Relationship
Grant Support
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Arachidonic Acids; 0/Cannabinoids; 0/Polyunsaturated Alkamides; 94421-68-8/anandamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hypoxia and neuronal function under in vitro conditions.
Next Document:  Therapeutic aspects of polymorphic epithelial mucin in adenocarcinoma.