Document Detail

The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food.
MedLine Citation:
PMID:  15821957     Owner:  NLM     Status:  MEDLINE    
RATIONALE: The CB1 receptor antagonist SR141716A reduces food intake in rats. This effect is likely to depend on modulation of reward related processes. OBJECTIVE: To investigate the effects of SR141716A on responding for food under a second order instrumental task in which responding and consumption of food can be separated, and on Pavlovian responding for a stimulus predictive of food reward. METHODS: Instrumental responding and pellet consumption following administration of SR141716A (0-3 mg/kg) were recorded under an FI5 min FR5(5:S) operant schedule that incorporates both a 5 min initial appetitive phase and a 25 min consummatory phase. We compared the drug-induced change in responding to that recorded following a reduction in motivational state induced by pre-feeding. In a second experiment we assessed the effects of SR141716A (0-3 mg/kg) on Pavlovian approach behaviour for a stimulus (lever) associated with food reward (CS+) and a neutral stimulus (lever) not associated with reward (CS-). RESULTS: SR141716A reduced pellet consumption and instrumental responding during both the appetitive and consummatory phases of the second order schedule. Pre-feeding had a similar effect on responding during the appetitive phase, suggesting an effect on incentive motivation. SR141716A also blocked an enhancement of responding that occurred during the consummatory phase in pre-fed animals. SR141716A and pre-feeding had no effect on responding in the Pavlovian autoshaping paradigm. CONCLUSIONS: SR141716A impacts on motivational processes in both the appetitive and consummatory phases of feeding behaviour.
Zoë D Thornton-Jones; Steven P Vickers; Peter G Clifton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-18
Journal Detail:
Title:  Psychopharmacology     Volume:  179     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-10-13     Revised Date:  2007-10-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  452-60     Citation Subset:  IM    
Department of Psychology, John Maynard-Smith Building, University of Sussex, Brighton, Sussex, BN1 9QG, UK.
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MeSH Terms
Appetite Depressants*
Conditioning, Classical / drug effects
Consummatory Behavior / drug effects*
Dose-Response Relationship, Drug
Eating / drug effects
Habituation, Psychophysiologic / drug effects
Piperidines / pharmacology*
Pyrazoles / pharmacology*
Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
Reinforcement (Psychology)
Reinforcement Schedule
Reg. No./Substance:
0/Appetite Depressants; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 158681-13-1/rimonabant

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