| A canine iliac artery occlusion model. | |
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MedLine Citation:
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PMID: 8452824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes an occlusive canine iliac artery model for use in experimental angioplasty procedures. Lesions were induced by overdistending and breaking the internal elastic lamina of the artery and implanting a 2-cm long occlusive collagen plug. The collagen plug diameter was varied to fit the iliac artery and caused immediate bilateral iliac occlusions. Histology of the lesions at 9 and 14 days (n = 2) showed that the lumen was filled with a mixture of fresh thrombus and collagen pad material (more collagen than thrombus) with focal disruptions of the internal elastic lamina. At 36 days (n = 2) the lumen was obliterated with a mixture of organizing thrombus and collagen pad material (more organizing thrombus than collagen). At 60 (n = 4) and 80 (n = 8) days the collagen pad had been completely replaced with organizing thrombus consisting of collagen fibers and hemosiderin-laden macrophages with persistent focal disruptions of the internal elastic lamina. These initial data demonstrate the ability to create fibrotic arterial occlusions in as short a time as 60 days and to provide a practical model to study methods for treating localized peripheral vascular occlusive disease. |
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Authors:
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G Kopchok; R A White; M Tabbara; D Cavaye; F Cormier; S K Peng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of investigative surgery : the official journal of the Academy of Surgical Research Volume: 6 ISSN: 0894-1939 ISO Abbreviation: J Invest Surg Publication Date: 1993 Jan-Feb |
Date Detail:
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Created Date: 1993-04-22 Completed Date: 1993-04-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8809255 Medline TA: J Invest Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Department of Surgery, Harbor-University of California, Los Angeles Medical Center, Torrance 90509. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / etiology*, pathology Arteriosclerosis / etiology, pathology Disease Models, Animal* Dogs Female Iliac Artery* / pathology |
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