| A canine coronary artery thrombosis model: application of photochemically induced thrombosis. | |
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MedLine Citation:
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PMID: 8849307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple and reproducible canine model of platelet-rich coronary artery thrombosis, suitable for the evaluation of antithrombotic drugs, has been developed. In this model, thrombus was initiated in the left arterial descending coronary artery by means of transmural green light (540 nm) in the presence of i.v. administered rose bengal (a photosensitizer dye). The photochemical reaction between green light and rose bengal causes endothelial injury which is followed by platelet adhesion aggregation and formation of an occlusive platelet-rich thrombus at the site of the photochemical reaction. In 9 out of 12 animals, occlusion of the coronary artery occurred within 60 min after irradiation with green light and infusion of rose bengal. Infusion of tissue-type plasminogen activator (50,000 IU/kg) produced thrombolysis in 6 out of 9 animals within 60 min. Reocclusion was observed in 4 of these 6 animals. Photochemically induced thrombosis in the canine coronary artery provides a simple and platelet-rich thrombosis model suitable for the evaluation of antithrombotic and thrombolytic preparations. |
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Authors:
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K Umemura; M Ishiye; S Araki; M Nakashima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 330 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1995 Jul-Aug |
Date Detail:
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Created Date: 1996-10-22 Completed Date: 1996-10-22 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 13-24 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Thrombosis / chemically induced*, physiopathology Coronary Vessels / physiopathology* Disease Models, Animal* Dogs Female Male Tissue Plasminogen Activator / adverse effects* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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