| Is cancer promotion associated with dysfunction in co-operation between differentiated cells? | |
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MedLine Citation:
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PMID: 8819119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a selection-based computer model system we demonstrated that deteriorating cellular co-operation between differentiated cells could result in positive selection for initiated cells of high proliferative capacity. The ratio of the initiated cells to their normal counterparts increased from 0.47 to 0.63 when the strength of co-operation decreased to one hundredth. The correlation proved to be significant. A number of bioactive substances involved in cell-to-cell communication are already registered as cocarcinogens. Whether this approach can explain the role of other promoting agents remains to be answered. It is also possible that the high incidence rate of old-age cancer may be in part accounted for by this kind of co-operational failure during senescence. |
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Authors:
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L Kozma; A Hadházi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 47 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1997-02-13 Completed Date: 1997-02-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 65-8 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory of Informatics, University Medical School of Debrecen, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens* Cell Communication Cell Death Cell Differentiation* Cell Transformation, Neoplastic* Computer Simulation Humans Models, Biological* Neoplasms / chemically induced, pathology*, physiopathology* Probability |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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