Document Detail

Is cancer promotion associated with dysfunction in co-operation between differentiated cells?
MedLine Citation:
PMID:  8819119     Owner:  NLM     Status:  MEDLINE    
In a selection-based computer model system we demonstrated that deteriorating cellular co-operation between differentiated cells could result in positive selection for initiated cells of high proliferative capacity. The ratio of the initiated cells to their normal counterparts increased from 0.47 to 0.63 when the strength of co-operation decreased to one hundredth. The correlation proved to be significant. A number of bioactive substances involved in cell-to-cell communication are already registered as cocarcinogens. Whether this approach can explain the role of other promoting agents remains to be answered. It is also possible that the high incidence rate of old-age cancer may be in part accounted for by this kind of co-operational failure during senescence.
L Kozma; A Hadházi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  47     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Department of Pathology and Laboratory of Informatics, University Medical School of Debrecen, Hungary.
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MeSH Terms
Cell Communication
Cell Death
Cell Differentiation*
Cell Transformation, Neoplastic*
Computer Simulation
Models, Biological*
Neoplasms / chemically induced,  pathology*,  physiopathology*
Reg. No./Substance:

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