| A canarypox vector expressing cytomegalovirus (CMV) glycoprotein B primes for antibody responses to a live attenuated CMV vaccine (Towne). | |
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MedLine Citation:
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PMID: 10438376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To develop a vaccine against cytomegalovirus (CMV), a canarypox virus (ALVAC) expressing CMV glycoprotein (gB) was evaluated alone or in combination with a live, attenuated CMV vaccine (Towne). Three doses of 106.5 TCID50 of ALVAC-CMV(gB) induced very low neutralizing or ELISA antibodies in most seronegative adults. However, to determine whether ALVAC-CMV(gB) could prime for antibody responses, 20 seronegative adults randomly received either 106.8 TCID50 of ALVAC-CMV(gB) or 106.8 TCID50 of ALVAC-RG, expressing the rabies glycoprotein, administered at 0 and 1 month, with all subjects receiving a dose of 103.5 pfu of the Towne vaccine at 90 days. For subjects primed with ALVAC-CMV(gB), neutralizing titers and ELISA antibodies to CMV(gB) developed sooner, were much higher, and persisted longer than for subjects primed with ALVAC-RG. All vaccines were well tolerated. These results demonstrate that ALVAC-CMV(gB) primes the immune system and suggest a combined-vaccine strategy to induce potentially protective levels of neutralizing antibodies. |
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Authors:
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S P Adler; S A Plotkin; E Gonczol; M Cadoz; C Meric; J B Wang; P Dellamonica; A M Best; J Zahradnik; S Pincus; K Berencsi; W I Cox; Z Gyulai |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 180 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-23 Completed Date: 1999-09-23 Revised Date: 2008-08-26 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 843-6 Citation Subset: AIM; IM |
Affiliation:
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Medical College of Virginia/Virginia Commonwealth University, Richmond, VA 23298-0163, USA. SADLER@HSC.VCU.EDU |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Viral / blood Antibody Formation Avipoxvirus / genetics, immunology* Cytomegalovirus / genetics, immunology* Cytomegalovirus Infections / immunology*, prevention & control Double-Blind Method Enzyme-Linked Immunosorbent Assay Female Genetic Vectors Humans Male Middle Aged Vaccines, Attenuated / adverse effects, immunology* Viral Envelope Proteins / immunology* Viral Vaccines / adverse effects, immunology* |
| Chemical | |
Reg. No./Substance:
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0/ALVAC vaccine; 0/Antibodies, Viral; 0/Vaccines, Attenuated; 0/Viral Envelope Proteins; 0/Viral Vaccines; 0/glycoprotein B, Simplexvirus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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