| Is calmodulin involved in the regulation of gap junction permeability? | |
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MedLine Citation:
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PMID: 6316253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell-to-cell channels of gap junctions mediate the direct exchange of ions and small metabolites between neighboring cells. A number of studies have shown that these channels close when the intracellular free calcium or hydrogen concentration increases, the result being cell-to-cell uncoupling. Since most of the calcium-activated biological phenomena are mediated by calmodulin (CaM), an obvious question is whether or not CaM is involved in the mechanism of cell coupling regulation. Data from the present study, showing the inhibitory effects of a calmodulin blocker on electrical uncoupling in Xenopus embryo cells, suggest a possible CaM participation in the uncoupling mechanism. |
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Authors:
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C Peracchia; G Bernardini; L L Peracchia |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 399 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1984-01-27 Completed Date: 1984-01-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 152-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / pharmacology Calmodulin / physiology* Embryo, Nonmammalian Intercellular Junctions / physiology* Ion Channels / physiology* Permeability Rana pipiens Trifluoperazine / pharmacology Xenopus laevis |
| Grant Support | |
ID/Acronym/Agency:
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GM 20113/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 0/Ion Channels; 117-89-5/Trifluoperazine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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