Document Detail


Is calmodulin involved in the regulation of gap junction permeability?
MedLine Citation:
PMID:  6316253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell-to-cell channels of gap junctions mediate the direct exchange of ions and small metabolites between neighboring cells. A number of studies have shown that these channels close when the intracellular free calcium or hydrogen concentration increases, the result being cell-to-cell uncoupling. Since most of the calcium-activated biological phenomena are mediated by calmodulin (CaM), an obvious question is whether or not CaM is involved in the mechanism of cell coupling regulation. Data from the present study, showing the inhibitory effects of a calmodulin blocker on electrical uncoupling in Xenopus embryo cells, suggest a possible CaM participation in the uncoupling mechanism.
Authors:
C Peracchia; G Bernardini; L L Peracchia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  399     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  152-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / pharmacology
Calmodulin / physiology*
Embryo, Nonmammalian
Intercellular Junctions / physiology*
Ion Channels / physiology*
Permeability
Rana pipiens
Trifluoperazine / pharmacology
Xenopus laevis
Grant Support
ID/Acronym/Agency:
GM 20113/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Calmodulin; 0/Ion Channels; 117-89-5/Trifluoperazine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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