Document Detail


A calf model for left ventricular centrifugal mechanical assist.
MedLine Citation:
PMID:  8817975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increased use of centrifugal mechanical assist (CMA) for treatment of refractory postcardiotomy cardiogenic shock highlights the need for experimental testing to improve clinical results. This report describes the preoperative conditioning, anesthetic and surgical technique, and postoperative management of a reliable calf model refined in this laboratory for in vivo subchronic (96 h) testing of CMA. Holstein bull calves (2 to 3 months old; mean body weight, 78 kg; n = 35) were instrumented for left ventricular CMA; 4 of these calves were sham-operated controls. Anesthetic recovery and postoperative restraint were accomplished in a specially designed crate to which each calf was preconditioned extensively. Younger calves were more readily conditioned and more tolerant of postoperative restraint than older calves. One calf died of ventricular fibrillation intraoperatively. One calf that had been heparinized developed uncontrollable hemothorax and died 12 h postoperatively. One calf prematurely dislodged his aortic cannula 15 h postoperatively and exsanguinated. Six calves developed pelvic limb paresis or paralysis because of lumbar spinal cord thromboembolism by 36 h postoperatively, and 3 of these calves were sacrificed by 42 h postoperatively. Fifteen calves required sedation in the first 12 h after the operation. Tachycardia associated with bottle feeding occurred in 15 calves. Second-degree atrioventricular block was noted frequently during deep relaxation. Postmortem examination demonstrated the absence of surgical wound and distant infection, security of cannulae in all but the calf that prematurely dislodged the aortic cannula, absence of thrombus formation at cannulation sites, and presence of thromboembolism in 51% of the calves. The incidence of thromboembolic lesions was not influenced by the need for chemical restraint, by the occurrence of feeding-associated tachycardia, or by the presence of atrioventricular block. There were no thromboembolic lesions in any of the sham-operated controls.
Authors:
F A Mann; C C Wagner-Mann; J J Curtis; T L Demmy; J R Turk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  20     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  670-7     Citation Subset:  IM    
Affiliation:
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia / standards
Animals
Cattle
Centrifugation
Disease Models, Animal
Heart-Assist Devices / adverse effects,  standards*
Heparin / administration & dosage,  therapeutic use
Intraoperative Complications / prevention & control
Male
Postoperative Complications / prevention & control
Preoperative Care / standards
Shock, Cardiogenic / therapy
Thromboembolism / physiopathology,  prevention & control
Ventricular Fibrillation / mortality
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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