Document Detail

The calcium controversy revisited: implications of new data.
MedLine Citation:
PMID:  8166791     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review and synthesis recent literature relating to the skeletal effects of dietary calcium supplementation. DATA SOURCES: Six recent randomised controlled clinical trials are reviewed together with other relevant clinical and physiological studies. CONCLUSIONS: Recent controlled clinical trials of the effect of dietary calcium supplementation in postmenopausal women have supported the conclusion that increasing calcium intake can slow bone loss at appendicular and axial skeletal sites. Supplementation may be more effective in those with a low calcium intake or when combined with an exercise regimen in those with low bone mass, and was more effective in women further from the menopause. Calcium has its effect by reducing bone resorption. The effect of dietary calcium on bone is due to the absorbed fraction which is influenced negatively by other dietary factors such as dietary fibre and positively by the circulating concentration of the active form of vitamin D, calcitriol. To improve the efficacy of calcium supplements it will be necessary to optimise absorption. Nevertheless, in the light of these recent trials it would be reasonable to consider increasing the Australian recommended dietary intake for postmenopausal women to 1500 mg calcium per day.
R Prince
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  159     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  404-7     Citation Subset:  IM    
Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands.
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MeSH Terms
Bone Density / drug effects
Calcium, Dietary / administration & dosage*,  metabolism,  pharmacology
Fractures, Bone / prevention & control
Intestinal Absorption
Osteoporosis, Postmenopausal / metabolism,  prevention & control*
Randomized Controlled Trials as Topic
Vitamin D / metabolism
Reg. No./Substance:
0/Calcium, Dietary; 1406-16-2/Vitamin D
Comment In:
Med J Aust. 1994 Feb 7;160(3):162-3   [PMID:  8295591 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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