Document Detail


The calcium antagonist isradipine and its effect on blood pressure related to plasma renin activity.
MedLine Citation:
PMID:  2140943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to test the hypothesis that peripheral vein plasma renin activity is a determinant of the magnitude of the hypotensive effect of the calcium antagonist Isradipine when given to mild to moderately severe essential hypertensives. There was significant relationship between plasma renin activity and blood pressure reduction by Isradipine. The lower the plasma renin activity the greater the blood pressure reduction. Both plasma volume and initial diastolic blood pressure level were not determinants. Thus, low peripheral vein plasma renin activity is a determinant (marker) of the hypotensive effect of Isradipine in mild to moderately severe uncomplicated essential hypertensives.
Authors:
A A Carr; L M Prisant
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  3     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Medical College of Georgia, Augusta 30912-3150.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*
Calcium Channel Blockers / pharmacology*
Diastole
Female
Humans
Hypertension / physiopathology
Isradipine
Male
Middle Aged
Norepinephrine / blood
Pyridines / pharmacology*
Renin / blood*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Pyridines; 51-41-2/Norepinephrine; 75695-93-1/Isradipine; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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