Document Detail

cGMP-dependent protein kinase: linking foraging to energy homeostasis.
MedLine Citation:
PMID:  19132066     Owner:  NLM     Status:  MEDLINE    
Successful foraging is necessary for procurement of nutritional resources essential for an animal's survival. Maintenance of foraging and food acquisition is dependent on the ability to balance food intake and energy expenditure. This review examines the role of cGMP-dependent protein kinase (PKG) as a regulator of foraging behaviour, food acquisition, and energy balance. The role of PKG in food-related behaviours is highly conserved among worms, flies, bees, ants, and mammals. A growing body of literature suggests that PKG plays an integral role in the component behaviours and physiologies underlying foraging behaviour. These include energy acquisition, nutrient absorption, nutrient allocation, nutrient storage, and energy use. New evidence suggests that PKG mediates both neural and physiological mechanisms underlying these processes. This review illustrates how investigating the role of PKG in energy homeostasis in a diversity of organisms can offer a broad perspective on the mechanisms mediating energy balance.
Karla R Kaun; Marla B Sokolowski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Genome / National Research Council Canada = Génome / Conseil national de recherches Canada     Volume:  52     ISSN:  0831-2796     ISO Abbreviation:  Genome     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-05-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8704544     Medline TA:  Genome     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Biology, University of Toronto, 3359 Mississauga Road, Mississauga, ON L5L1C6, Canada.
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MeSH Terms
Caenorhabditis elegans
Cyclic GMP-Dependent Protein Kinases / metabolism*
Drosophila melanogaster
Eating / genetics
Feeding Behavior / physiology
Food Deprivation
Models, Biological
Models, Genetic
Nutritional Sciences
Species Specificity
Grant Support
5R01DK070141-03/DK/NIDDK NIH HHS
Reg. No./Substance:
EC GMP-Dependent Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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