Document Detail

cDermo-1 misexpression induces dense dermis, feathers, and scales.
MedLine Citation:
PMID:  15572138     Owner:  NLM     Status:  MEDLINE    
Reciprocal epithelio-mesenchymal interactions between the prospective epidermis and the underlying dermis are the major driving forces in the development of skin appendages. Feather development is initiated by a still unknown signal from the dermis in feather-forming skin. The morphological response of the ectoderm to this signal is the formation of an epidermal placode, which signals back to the mesenchyme to induce dermal condensations. Together, epidermal and dermal components constitute the outgrowing feather bud. The bHLH transcription factor cDermo-1 is expressed in developing dermis and is the earliest known marker of prospective feather tracts. To test its function during feather development, we forced cDermo-1 expression in embryonic chicken dermis using a retroviral expression vector. In featherless (apteric) regions, cDermo-1 misexpression induced dense, thickened dermis normally observed in feathered skin (pterylae), and leads to the development of regularly spaced and normally shaped ectopic feather buds. In pterylae, cDermo-1 misexpression enhanced feather growth. In hindlimb skin, according to the local skin identity, misexpression of cDermo-1 induced ectopic scale formation. Thus, we show that forced cDermo-1 expression in developing dermis is sufficient to launch the developmental program leading to skin appendage formation. We propose a role of cDermo-1 at the initial stages of feather induction upstream of FGF10.
Christoph Hornik; Kewal Krishan; Faisal Yusuf; Martin Scaal; Beate Brand-Saberi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  277     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-01     Completed Date:  2005-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-50     Citation Subset:  IM    
Institute of Anatomy and Cell Biology II, Albert-Ludwigs-Universität, D-79104 Freiburg, Germany.
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MeSH Terms
Avian Proteins
Body Patterning
Chick Embryo
Feathers / embryology*
Skin / embryology*
Transcription Factors / physiology*
Twist Transcription Factor
Reg. No./Substance:
0/Avian Proteins; 0/Transcription Factors; 0/Twist Transcription Factor; 0/Twist protein, Gallus gallus

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