Document Detail

cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation.
MedLine Citation:
PMID:  3494249     Owner:  NLM     Status:  MEDLINE    
We have isolated a human cDNA that is expressed in the intermediate and late stages of T-cell differentiation. The cDNA encodes a highly hydrophobic protein, termed MAL, that lacks a hydrophobic leader peptide sequence and contains four potential transmembrane domains separated by short hydrophilic segments. The predicted configuration of the MAL protein resembles the structure of integral proteins that form pores or channels in the plasma membrane and that are believed to act as transporters of water-soluble molecules and ions across the lipid bilayer. The presence of MAL mRNA in a panel of T-cell lines that express both the T-cell receptor and the T11 antigen suggests that MAL may be involved in membrane signaling in T cells activated via either T11 or T-cell receptor pathways.
M A Alonso; S M Weissman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  84     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-05-04     Completed Date:  1987-05-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1997-2001     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
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MeSH Terms
Amino Acid Sequence
Base Sequence
Carrier Proteins / genetics*
Cell Differentiation
Cell Line
Cells, Cultured
Cloning, Molecular*
DNA / isolation & purification,  metabolism*
Membrane Proteins / genetics*
Membrane Transport Proteins*
Myelin Proteins*
Protein Biosynthesis
Proteins / genetics*
RNA, Messenger / genetics
T-Lymphocytes / cytology,  immunology*
Reg. No./Substance:
0/Carrier Proteins; 0/MAL protein, T-cell; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/Myelin Proteins; 0/Proteins; 0/Proteolipids; 0/RNA, Messenger; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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