| cDNA cloning of the developmentally regulated lamin LIII of Xenopus laevis. | |
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MedLine Citation:
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PMID: 3181134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lamins are nucleoskeletal proteins which form intermediate type filaments in close association with the inner nuclear envelope membrane. Based on molecular and biochemical properties the lamins were grouped as type-A and type-B lamins, respectively. I have cloned the cDNA encoding lamin LIII of Xenopus which is the lamin protein present in oocyte nuclei and in cleavage nuclei. The data presented here indicate that a pool of maternal lamin LIII RNA is synthesized very early in oogenesis and that it continues to be present until gastrulation when the vast majority of the LIII RNA is degraded. Despite the similarities shared by all lamin proteins, the lamin LIII sequence neither possesses the features diagnostic for either type-A or type-B lamins nor does it show greater sequence similarity to one of the lamin types than to the other and thus it may represent a third type of lamin protein which may reflect its special function in oogenesis and early development. |
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Authors:
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R Stick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The EMBO journal Volume: 7 ISSN: 0261-4189 ISO Abbreviation: EMBO J. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-12-22 Completed Date: 1988-12-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8208664 Medline TA: EMBO J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3189-97 Citation Subset: IM |
Affiliation:
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Département de Biologie Moléculaire, Université de Genève, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA / genetics Lamins Molecular Sequence Data Molecular Weight Nuclear Proteins / genetics* Oogenesis Peptide Mapping Precipitin Tests Xenopus laevis / embryology, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Lamins; 0/Nuclear Proteins; 9007-49-2/DNA |
| Comments/Corrections | |
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