| cDNA expression analysis of a human radiosensitive-radioresistant cell line model identifies telomere function as a hallmark of radioresistance. | |
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MedLine Citation:
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PMID: 20726715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To achieve a more complete understanding of the molecular mechanisms underlying tumor radioresistance, we established a radioresistant cell line from the human larynx squamous cell carcinoma cell line Hep-2 after long-term radiation induction. The biological features of the resulting cell lines were characterized. cDNA microarray technology was used to measure the alterations of gene expression in the radioresistant cells. We found that certain genes associated with DNA repair, cell cycle, apoptosis, etc. were significantly changed. In particular, genes related to telomeres, such as POT1, were significantly altered. Radioresistant cells had higher telomerase activity and longer telomeres than their parental cells. Our research suggests that telomere function is a novel hallmark of cellular radiosensitivity, and the mechanistic link between telomere maintenance and radiosensitivity may involve the genes and pathways we implicated in this study. |
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Authors:
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Fu-Xiang Zhou; Jie Xiong; Zhi-Guo Luo; Jing Dai; Hai-Jun Yu; Zheng-Kai Liao; Han Lei; Cong-Hua Xie; Yun-Feng Zhou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-14 |
Journal Detail:
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Title: Radiation research Volume: 174 ISSN: 1938-5404 ISO Abbreviation: Radiat. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 550-7 Citation Subset: IM; S |
Affiliation:
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Department of Radio-Chemotherapy, Zhongnan Hospital, Wuhan University, Wuhan 430071, China. yfzhouwhu@163.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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genetics,
radiation effects Cell Line, Tumor Cell Proliferation / radiation effects Gene Expression Profiling* Humans Oligonucleotide Array Sequence Analysis* Radiation Tolerance / genetics*, radiation effects* Telomerase / metabolism Telomere / metabolism*, radiation effects* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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