Document Detail

cAMP levels in fast- and slow-twitch skeletal muscle after an acute bout of aerobic exercise.
MedLine Citation:
PMID:  8392799     Owner:  NLM     Status:  MEDLINE    
The present study examined whether exercise duration was associated with elevated and/or sustained elevations of postexercise adenosine 3',5'-cyclic monophosphate (cAMP) by measuring cAMP levels in skeletal muscle for up to 4 h after acute exercise bouts of durations that are known to either produce (60 min) or not produce (10 min) mitochondrial proliferation after chronic training. Treadmill-acclimatized, but untrained, rats were run at 22 m/min for 0 (control), 10, or 60 min and were killed at various postexercise (0, 0.5, 1, 2, and 4 h) time points. Fast-twitch white and red (quadriceps) and slow-twitch (soleus) muscles were quickly excised, frozen in liquid nitrogen, and assayed for cAMP with a commercial kit. Unexpectedly, cAMP contents in all three muscles were similar to control (nonexercise) at most (21 of 30) time points after a single 10- or 60-min run. Values at 9 of 30 time points were significantly different from control (P < 0.05); i.e., 3 time points were significantly higher than control and 6 were significantly less than control. These data suggest that the cAMP concentration of untrained skeletal muscle after a single bout of endurance-type exercise is not, by itself, associated with exercise duration.
A Sheldon; F W Booth; C R Kirby
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-13     Completed Date:  1993-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  C1500-4     Citation Subset:  IM; S    
Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225.
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MeSH Terms
Cyclic AMP / metabolism*
Isoproterenol / pharmacology
Muscle Contraction*
Muscles / metabolism*
Osmolar Concentration
Phosphodiesterase Inhibitors / pharmacology
Physical Conditioning, Animal*
Rats, Sprague-Dawley
Time Factors
Trichloroacetic Acid
Grant Support
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 60-92-4/Cyclic AMP; 64-17-5/Ethanol; 76-03-9/Trichloroacetic Acid; 7683-59-2/Isoproterenol
C R Kirby / U TX Med Sch, Houston; F W Booth / U TX Med Sch, Houston

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