Document Detail

cAMP induces a transient elevation of cGMP levels during early culmination of Dictyostelium minutum.
MedLine Citation:
PMID:  2985287     Owner:  NLM     Status:  MEDLINE    
Oscillatory cAMP signals very likely organize the cell movement which leads to fruiting body construction in Dictyostelium minutum [Schaap, P., Konijn, T.M. and Van Haastert, P.J.M.: Proc. Natl. Acad. Sci. USA 81, 2122-2126 (1984)]. Stimulation with cAMP induces a transient elevation of cGMP in cells at the early culmination stage, which peaks at 12-18 s. A half maximal cGMP response is induced by 10(-7) M cAMP and saturation of the response is reached at 10(-5) M cAMP. No cGMP accumulation was induced by stimulation of vegetative or aggregative cells of D. minutum by cAMP. Since the transient increase of cGMP is most likely involved in the transduction of chemotactic signals, our results indicate that cAMP signals organize fruiting body formation by inducing chemotaxis inside the aggregate.
P Schaap; M Wang
Related Documents :
10744637 - Nitric oxide reduces vascular smooth muscle cell elastase activity through cgmp-mediate...
14527347 - Independence of circadian entrainment state and responses to melatonin in male siberian...
18319447 - Meeting report: cgmp matters.
19029137 - Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy ind...
2988537 - Polymyxin b causes coordinate inhibition of phorbol ester-induced c-kinase activity and...
20888327 - Calcium/calmodulin-dependent kinase ii facilitated glur6 subunit serine phosphorylation...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell differentiation     Volume:  16     ISSN:  0045-6039     ISO Abbreviation:  Cell Differ.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-12     Completed Date:  1985-06-12     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0342640     Medline TA:  Cell Differ     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chemotaxis / drug effects
Cyclic AMP / pharmacology*
Cyclic GMP / metabolism*
Dictyostelium / drug effects,  metabolism*
Reg. No./Substance:
60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by...
Next Document:  The interaction of resealed reticulocyte ghosts with Fe3+-transferrin-CO3(2-).