Document Detail

c-myc protein expression during cell cycle phases in differentiating HL-60 cells.
MedLine Citation:
PMID:  7920226     Owner:  NLM     Status:  MEDLINE    
We examined c-myc protein expression in cell cycle phases during differentiation induction of HL-60 cells by flow cytometry using an indirect immunofluorescence method. In exponentially proliferating HL-60 cells, c-myc protein was expressed in a cell cycle dependent manner. During the differentiation induction of HL-60 cells with dimethylsulfoxide (DMSO), c-myc protein was rapidly down-regulated in the G1/0 specific phase prior to the appearance of differentiation associated markers. Our results indicate that c-myc protein functions in the G1/0 specific phase in cellular differentiation, and the rapid down-regulation of c-myc protein in G1/0 phase is closely associated with initial differentiation programs.
S Kumakura; H Ishikura; H Tsumura; H Hayashi; J Endo; T Tsunematsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  14     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-14     Completed Date:  1994-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  171-80     Citation Subset:  IM    
Third Division of Internal Medicine, Shimane Medical University, Izumo, Japan.
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MeSH Terms
Cell Cycle
Cell Differentiation / drug effects
Cell Division
Dimethyl Sulfoxide / pharmacology
Flow Cytometry
Fluorescent Antibody Technique
Gene Expression Regulation, Leukemic*
Leukemia, Promyelocytic, Acute / pathology*
Neoplasm Proteins / biosynthesis*,  genetics
Proto-Oncogene Proteins c-myc / biosynthesis*,  genetics
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/Neoplasm Proteins; 0/Proto-Oncogene Proteins c-myc; 67-68-5/Dimethyl Sulfoxide

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