| c-myc protein expression during cell cycle phases in differentiating HL-60 cells. | |
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MedLine Citation:
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PMID: 7920226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined c-myc protein expression in cell cycle phases during differentiation induction of HL-60 cells by flow cytometry using an indirect immunofluorescence method. In exponentially proliferating HL-60 cells, c-myc protein was expressed in a cell cycle dependent manner. During the differentiation induction of HL-60 cells with dimethylsulfoxide (DMSO), c-myc protein was rapidly down-regulated in the G1/0 specific phase prior to the appearance of differentiation associated markers. Our results indicate that c-myc protein functions in the G1/0 specific phase in cellular differentiation, and the rapid down-regulation of c-myc protein in G1/0 phase is closely associated with initial differentiation programs. |
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Authors:
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S Kumakura; H Ishikura; H Tsumura; H Hayashi; J Endo; T Tsunematsu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 14 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-11-14 Completed Date: 1994-11-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 171-80 Citation Subset: IM |
Affiliation:
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Third Division of Internal Medicine, Shimane Medical University, Izumo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Cell Differentiation / drug effects Cell Division Dimethyl Sulfoxide / pharmacology Flow Cytometry Fluorescent Antibody Technique Gene Expression Regulation, Leukemic* Humans Leukemia, Promyelocytic, Acute / pathology* Male Neoplasm Proteins / biosynthesis*, genetics Proto-Oncogene Proteins c-myc / biosynthesis*, genetics Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Proto-Oncogene Proteins c-myc; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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