| c-myc, c-erbB-2, and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast carcinoma. | |
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MedLine Citation:
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PMID: 1348967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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c-myc, c-erbB-2, and Ki-67 expression was examined by immunohistochemistry in 11 normal breast tissues and 42 invasive and 14 noninvasive breast carcinomas. The c-myc product was detected in all breast carcinoma specimens and in 7 of 11 normal breast tissues. Invasive tumors stained more frequently with the anti-myc monoclonal antibody than did noninvasive tumors, while the level of expression in normal breast tissue was much less than that in breast cancer. Membrane staining of the c-erbB-2 protein was demonstrated in 29% (4 of 14) of noninvasive ductal carcinomas and in 45% (19 of 42) of invasive breast carcinomas. None of the 11 normal breast tissue samples was positive. The mean value of Ki-67-positive cells was 0.91 +/- 0.31% for normal breast tissue, 4.57 +/- 1.36% for noninvasive ductal carcinoma, and 12.76 +/- 2.18% for invasive breast cancer. In 42 invasive breast carcinomas, the expression of c-myc, c-erbB-2, and Ki-67 proliferation marker were compared with lymph node status, estrogen receptor status, progesterone receptor status, and age of patients at diagnosis. c-erbB-2 overexpression and Ki-67 overexpression were identified as the only factors associated with lymph node status. We concluded that they might be additional prognostic factors for breast carcinoma. |
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Authors:
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Z P Pavelic; L Pavelic; E E Lower; M Gapany; S Gapany; E A Barker; H D Preisler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 52 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-05-26 Completed Date: 1992-05-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2597-602 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Cincinnati, Ohio 45267-0528. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast
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chemistry* Breast Neoplasms / chemistry* Female Humans Ki-67 Antigen Nuclear Proteins / analysis* Prognosis Proto-Oncogene Proteins / analysis* Proto-Oncogene Proteins c-myc / analysis* Receptor, erbB-2 |
| Grant Support | |
ID/Acronym/Agency:
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CA 41285/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-myc; EC 2.7.10.1/Receptor, erbB-2 |
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