Document Detail

c-fos/c-jun expression and AP-1 activation in skin fibroblasts from centenarians.
MedLine Citation:
PMID:  8806666     Owner:  NLM     Status:  MEDLINE    
In vitro replicative senescence is characterized by an irreversible growth arrest due to the inability of the cell to induce some key regulators of cell cycle progression, such as c-fos and AP-1, in response to mitogenic stimuli. In vitro replicative senescence and in vivo aging have been assumed to be two related phenomena, likely controlled by overlapping or interacting genes. As a corollary, fibroblasts from centenarians, which have undergone a long process of senescence in vivo should have very limited proliferative capability. On the contrary, in a previous work we found that fibroblasts from centenarians exhibited the same capacity to respond to different mitogenic stimuli as fibroblasts from young donors. Here we provide evidences that the well preserved proliferative response is likely due to the fact that some pivotal regulators- c-fos, c-jun and AP-1-are still fully inducible, despite a long process of in vivo senescence. Our data therefore suggest that in vivo and in vitro aging are separate phenomena whose possible relationships, if any, have to be ascertained very carefully.
E Grassilli; E Bellesia; P Salomoni; M A Croce; E Sikora; E Radziszewska; G Tesco; M Vergelli; S Latorraca; D Barbieri; U Fagiolo; S Santacaterina; L Amaducci; R Tiozzo; S Sorbi; C Franceschi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  226     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-22     Completed Date:  1996-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  517-23     Citation Subset:  IM    
Department of Biomedical Sciences, University of Modena, Italy.
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MeSH Terms
Aged, 80 and over
Aging / genetics*
Base Sequence
Cyclic AMP Response Element-Binding Protein / metabolism
DNA / metabolism
DNA Primers
Fibroblasts / metabolism
Genes, fos*
Genes, jun*
Middle Aged
Molecular Sequence Data
Protein Binding
Skin / cytology,  metabolism*
Transcription Factor AP-1 / metabolism*
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein; 0/DNA Primers; 0/Transcription Factor AP-1; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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