| c-erbB 2 serum level as prognostic factor in hormonally treated advanced breast cancer patients. | |
| | |
MedLine Citation:
|
PMID: 14965684 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
To investigate whether c-erbB 2 serum levels may be predictive of clinical response, progression-free and overall survival in postmenopausal women with advanced breast cancer hormonally treated, 265 patients enrolled in previous clinical trials were evaluated. C-erbB 2 serum levels were assessed before the start of treatment and in a subgroup of patients also at the first response evaluation. In addition, serum CA 15.3 levels were determined. The role of c-erbB 2 was investigated by means of multiple regression models in which both c-erbB 2 and CA 15.3 values were modelled as continuous variables together with other known prognostic factors. The failure probability tended to be higher in the presence of high c-erbB 2 levels, but the trend was not statistically significant; in contrast, significant results were obtained for progression-free survival (PFS,P <0.001) and overall survival (OS, P=0.014). The within-patient c-erbB 2 variation significantly predicted PFS (P=0.006) and OS (P=0.040). It is worth noting that c-erbB 2 and CA 15.3 baseline levels were significantly correlated and that the prognostic effect of c-erbB 2 tended to disappear in the presence of high CA 15.3 levels for PFS and OS. |
| | |
Authors:
|
N Zilembo; L Mariani; A Martinetti; R Miceli; E Seregni; E Bichisao; I La Torre; P Pozzi; L Ferrari; D De Candis; V R Longarini; E Bajetta; E Bombardieri |
Related Documents
:
|
1616024 - Kinetics of 1,25-dihydroxyvitamin d metabolism in the aging rat. 20211254 - Regulatory t cell function correlates with serum 25-hydroxyvitamin d, but not with 1,25... 20649764 - Early intervention with intravenous or pulse oral vitamin d therapy is more effective i... 6806674 - Change in serum bicarbonate during acute edta infusions in post-transplant hyperparathy... 1884284 - Circadian rhythms of osteocalcin in equine serum. correlation with alkaline phosphatase... 4345054 - Hypolipidemic effect of pregnancy in the rabbit. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Breast (Edinburgh, Scotland) Volume: 11 ISSN: 0960-9776 ISO Abbreviation: Breast Publication Date: 2002 Aug |
Date Detail:
|
Created Date: 2004-02-17 Completed Date: 2004-02-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9213011 Medline TA: Breast Country: Scotland |
Other Details:
|
Languages: eng Pagination: 286-94 Citation Subset: - |
Affiliation:
|
Medical Oncology Unit B, Istituto Nazionale per lo Studio e la Cura dei Tumori, via Venezian 1, 20133 Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular markers in breast cancer: can we use c-erbB-2, p53, bcl-2 and bax gene expression as progn...
Next Document: Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue fro...