| c-Ret-mediated hearing losses. | |
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MedLine Citation:
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PMID: 22295143 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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About 120 million people worldwide suffer from congenital (early-onset) hearing loss. Thirty percent of them have syndromic hearing loss and the remaining 70% have non-syndromic hearing loss. In addition, a large number of elderly people worldwide suffer from age-related (late-onset) hearing loss. c-Ret and c-RET have been shown to be essential for the development and maintenance of neurons including the enteric nervous system (ENS) in mice and humans. Impairments of endothelin receptor B (EDNRB) and SOX10 have been shown to cause a significantly increased risk of dominant sensorineural deafness in Hirschsprung disease (HSCR) patients. We have recently shown that impairments of tyrosine 1062 (Y1062) phosphorylation in c-Ret causes syndromic congenital deafness in mice and humans and non-syndromic age-related hearing loss with neurodegeneration of spiral ganglion neurons (SGNs) in mice. This review focuses on the pathogenesis of hearing loss caused by impairments of c-Ret. |
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Authors:
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Nobutaka Ohgami; Haruka Tamura; Kyoko Ohgami; Machiko Iida; Ichiro Yajima; Mayuko Y Kumasaka; Yuji Goto; Michihiko Sone; Tsutomu Nakashima; Masashi Kato |
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Publication Detail:
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Type: Journal Article Date: 2012-01-01 |
Journal Detail:
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Title: International journal of clinical and experimental pathology Volume: 5 ISSN: 1936-2625 ISO Abbreviation: Int J Clin Exp Pathol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101480565 Medline TA: Int J Clin Exp Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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