Document Detail


The c-Myb oncoprotein.
MedLine Citation:
PMID:  9693954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The c-myb gene is the cellular homologue of the v-myb oncogenes carried by the avian leukaemia viruses AMV and E26. It encodes a transcription factor (c-Myb), as does each of the viral oncogenes, which recognises the core DNA sequence C/T-A-A-C-G/T-G via a repeated helix-turn-helix-like motif. c-myb is expressed in immature haemopoietic cells, as well as immature cells of the gastro-intestinal epithelium and is down-regulated with differentiation. Enforced expression of activated or even normal forms of Myb can transform haemopoietic cells, most often of the myeloid lineage, in vitro and in vivo. Although many genes have been identified which are likely to be regulated by c-Myb, the critical target genes involved in Myb's transforming activity are not known. Together with data showing increased c-myb expression in colonic tumours, these observations raise the possibility that c-myb may play a role in human malignant disease.
Authors:
T J Gonda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  30     ISSN:  1357-2725     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-08     Completed Date:  1998-09-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Affiliation:
Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia. tom.gonda@imvs.sa.gov.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Disease / etiology
Humans
Protein Conformation
Proto-Oncogene Proteins* / biosynthesis,  chemistry,  metabolism,  physiology
Proto-Oncogene Proteins c-myb
Trans-Activators* / biosynthesis,  chemistry,  metabolism,  physiology
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-myb; 0/Trans-Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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