Document Detail

c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid.
MedLine Citation:
PMID:  9305908     Owner:  NLM     Status:  MEDLINE    
Retinoic acid induces P19 mouse embryonal carcinoma cells to differentiate to endoderm and increases expression of the heterotrimeric G-protein subunits Galpha12 and Galpha13. Retinoic acid was found to induce differentiation and sustained activation of c-Jun amino-terminal kinase, but not of ERK1,2 or of p38 mitogen-activated protein kinases. Much like retinoic acid, expression of constitutively active forms of Galpha12 and Galpha13 induced differentiation and constitutive activation of c-Jun amino-terminal kinase. Expression of the dominant negative form of c-Jun amino-terminal kinase 1 blocked both the activation of c-Jun amino-terminal kinase and the induction of endodermal differentiation in the presence of retinoic acid. These data implicate c-Jun amino-terminal kinase as a downstream element of activation of Galpha12 or Galpha13 obligate for retinoic acid-induced differentiation.
E H Jho; R J Davis; C C Malbon
Related Documents :
8631598 - Different mechanisms are responsible for c-jun mrna induction by cisplatin and ultravio...
9858538 - Glutamate induces phosphorylation of elk-1 and creb, along with c-fos activation, via a...
1335418 - Activation of protein kinase c and elevation of camp interact synergistically to raise ...
22835458 - Effect of dietary salt on regulation of tgf-β in the kidney.
20204738 - Rho kinase-mediated vasoconstriction in pulmonary hypertension.
22624708 - What a difference a phosphate makes: life or death decided by a single amino acid in mdm2.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  272     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24468-74     Citation Subset:  IM    
Department of Molecular Pharmacology, Diabetes & Metabolic Diseases Research Program, University Medical Center, State University of New York, Stony Brook, New York 11794-8651, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anisomycin / pharmacology
Antigens, CD15 / metabolism
Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
Carcinoma, Embryonal / pathology*
Cell Differentiation / drug effects*,  physiology
Embryonic and Fetal Development
Enzyme Activation
GTP-Binding Proteins / physiology*
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases*
Tretinoin / pharmacology*
Grant Support
Reg. No./Substance:
0/Antigens, CD15; 22862-76-6/Anisomycin; 302-79-4/Tretinoin; EC Protein Kinases; EC Mitogen-Activated Protein Kinases; EC Protein Kinases; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to ...
Next Document:  Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit.