Document Detail


c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid.
MedLine Citation:
PMID:  9305908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinoic acid induces P19 mouse embryonal carcinoma cells to differentiate to endoderm and increases expression of the heterotrimeric G-protein subunits Galpha12 and Galpha13. Retinoic acid was found to induce differentiation and sustained activation of c-Jun amino-terminal kinase, but not of ERK1,2 or of p38 mitogen-activated protein kinases. Much like retinoic acid, expression of constitutively active forms of Galpha12 and Galpha13 induced differentiation and constitutive activation of c-Jun amino-terminal kinase. Expression of the dominant negative form of c-Jun amino-terminal kinase 1 blocked both the activation of c-Jun amino-terminal kinase and the induction of endodermal differentiation in the presence of retinoic acid. These data implicate c-Jun amino-terminal kinase as a downstream element of activation of Galpha12 or Galpha13 obligate for retinoic acid-induced differentiation.
Authors:
E H Jho; R J Davis; C C Malbon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  272     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24468-74     Citation Subset:  IM    
Affiliation:
Department of Molecular Pharmacology, Diabetes & Metabolic Diseases Research Program, University Medical Center, State University of New York, Stony Brook, New York 11794-8651, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisomycin / pharmacology
Antigens, CD15 / metabolism
Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
Carcinoma, Embryonal / pathology*
Cell Differentiation / drug effects*,  physiology
Embryonic and Fetal Development
Enzyme Activation
GTP-Binding Proteins / physiology*
JNK Mitogen-Activated Protein Kinases
Mice
Mitogen-Activated Protein Kinases*
Tretinoin / pharmacology*
Grant Support
ID/Acronym/Agency:
DK-30111/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD15; 22862-76-6/Anisomycin; 302-79-4/Tretinoin; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinases; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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