| c-Jun promotes whereas JunB inhibits epidermal neoplasia. | |
| | |
MedLine Citation:
|
PMID: 21289643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Deregulation of the activator protein 1 (AP1) family gene regulators has been implicated in a wide range of diseases, including cancer. In this study we report that c-Jun was activated in human squamous cell carcinoma (SCC) and coexpression of c-Jun with oncogenic Ras was sufficient to transform primary human epidermal cells into malignancy in a regenerated human skin grafting model. In contrast, JunB was not induced in a majority of human SCC cells. Moreover, exogenous expression of JunB inhibited tumorigenesis driven by Ras or spontaneous human SCC cells. Conversely, the dominant-negative JunB mutant (DNJunB) promoted tumorigenesis, which is in contrast to the tumor-suppressor function of the corresponding c-Jun mutant. At the cellular level, JunB induced epidermal cell senescence and slowed cell growth in a cell-autonomous manner. Consistently, coexpression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation of p16 and filaggrin and downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4). These findings indicate that JunB and c-Jun differentially regulate cell growth and differentiation and induce opposite effects on epidermal neoplasia.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://www.nature.com/jid/journalclub. |
| | |
Authors:
|
Jane Y Jin; Hengning Ke; Russell P Hall; Jennifer Y Zhang |
Related Documents
:
|
7964603 - T cell-stimulatory fragments of foot-and-mouth disease virus released by mild treatment... 10698083 - Application of the polymerase chain reaction in determination of recombinant retrovirus... 7718503 - The morphology and physiology of a "mini-ommatidium" in the median optic nerve of limul... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-03 |
Journal Detail:
|
Title: The Journal of investigative dermatology Volume: 131 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-15 Completed Date: 2011-07-14 Revised Date: 2013-04-03 |
Medline Journal Info:
|
Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 1149-58 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, Duke University, Durham, North Carolina 27710-0001, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinoma, Squamous Cell / metabolism*, pathology Cell Aging Cell Culture Techniques Cell Differentiation Cyclin-Dependent Kinase 4 / metabolism Down-Regulation Humans Intermediate Filament Proteins / metabolism Male Mice Neoplasm Proteins / metabolism Oncogene Protein p21(ras) / metabolism* Proto-Oncogene Proteins c-jun / metabolism* Skin / metabolism Skin Neoplasms / metabolism*, pathology Skin Transplantation / pathology Transcription Factor AP-1 / metabolism Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
|
K01 AR051470-04/AR/NIAMS NIH HHS; K01 AR051470-05/AR/NIAMS NIH HHS; K01AR051470/AR/NIAMS NIH HHS; R01 AR057746/AR/NIAMS NIH HHS; R01 AR057746-01A1/AR/NIAMS NIH HHS; R01 AR057746-03/AR/NIAMS NIH HHS; R01AR57746/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Intermediate Filament Proteins; 0/Neoplasm Proteins; 0/P16 protein, human; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; 0/filaggrin; EC 2.7.11.22/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4; EC 3.6.5.2/Oncogene Protein p21(ras) |
| Comments/Corrections | |
Comment In:
|
J Invest Dermatol. 2011 May;131(5):1002
[PMID:
21494238
]
|
Erratum In:
|
J Invest Dermatol. 2011 Jun;131(6):1388 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dimethylfumarate inhibits angiogenesis in vitro and in vivo: a possible role for its antipsoriatic e...
Next Document: Left atrial diameter, flow-mediated dilation of brachial artery and target organ damage in Chinese p...