Document Detail

The butanol fraction of Eclipta prostrata (Linn) effectively reduces serum lipid levels and improves antioxidant activities in CD rats.
MedLine Citation:
PMID:  19083459     Owner:  NLM     Status:  MEDLINE    
Eclipta prostrata (Linn) has been used as a traditional medicinal plant to prevent lipidemia and atherosclerosis in Asia. However, its functional properties and the underlying mechanism of action have not been clearly defined. This study was conducted to elucidate the biological basis for hypolipidemic and antioxidant activities of E. prostrata. Charles River Sprague-Dawley CD rats (specific pathogen-free/viral antibody-free Crj/Bgi male, 180 +/- 10 g) were fed experimental diets supplemented with 0 mg (control), 25 mg (E25), 50 mg (E50), or 100 mg (E100) of a freeze-dried butanol fraction of E. prostrata per kilogram of diet for 6 weeks. Serum triacylglycerol and total cholesterol levels were significantly lower in the E50 and E100 groups by 9.8% to 19.0% and by 10.7% to 13.4%, respectively, and low-density lipoprotein-cholesterol levels were significantly reduced in the same groups by 10.3% to 13.0% compared with the untreated control group. The E50 and E100 groups also showed significantly increased high-density lipoprotein-cholesterol levels (13.0%-19.1%) compared with the control group. Atherogenic indices were decreased by 9.8% to 30.5% in all groups fed diets supplemented with E. prostrata. Furthermore, serum hydroxyl radical, lipid peroxide, and oxidized protein levels were significantly decreased in the E50 and E100 groups. These results clearly demonstrate the effects of E. prostrata on serum lipid and oxidative metabolism in rats. The health-promoting effects of E. prostrata, which were demonstrated in this study in a rat model, may have implications for atherosclerosis and hypercholesterolemia in humans.
Dae-Ik Kim; Sung-Hyen Lee; Jin-Ho Choi; Hyun Soon Lillehoj; Mi-Hee Yu; Gun-Soon Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  28     ISSN:  1879-0739     ISO Abbreviation:  Nutr Res     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-4     Citation Subset:  IM    
Department of Food Science and Biotechnology, Pukyong National University, Busan 608-737, South Korea.
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MeSH Terms
Antioxidants / analysis*
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Eclipta / chemistry*
Hydroxyl Radical / blood
Lipid Peroxides / blood
Lipids / blood*
Plant Extracts / administration & dosage*
Rats, Sprague-Dawley
Triglycerides / blood
Reg. No./Substance:
0/Antioxidants; 0/Butanols; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipid Peroxides; 0/Lipids; 0/Plant Extracts; 0/Triglycerides; 3352-57-6/Hydroxyl Radical; 57-88-5/Cholesterol

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