Document Detail

The burden of malaria in pregnancy in malaria-endemic areas.
MedLine Citation:
PMID:  11425175     Owner:  NLM     Status:  MEDLINE    
Pregnant women in malarious areas may experience a variety of adverse consequences from malaria infection including maternal anemia, placental accumulation of parasites, low birth weight (LBW) from prematurity and intrauterine growth retardation (IUGR), fetal parasite exposure and congenital infection, and infant mortality (IM) linked to preterm-LBW and IUGR-LBW. We reviewed studies between 1985 and 2000 and summarized the malaria population attributable risk (PAR) that accounts for both the prevalence of the risk factors in the population and the magnitude of the associated risk for anemia, LBW, and IM. Consequences from anemia and human immunodeficiency virus infection in these studies were also considered. Population attributable risks were substantial: malaria was associated with anemia (PAR range = 3-15%), LBW (8-14%), preterm-LBW (8-36%), IUGR-LBW (13-70%), and IM (3-8%). Human immunodeficiency virus was associated with anemia (PAR range = 12-14%), LBW (11-38%), and direct transmission in 20-40% of newborns, with direct mortality consequences. Maternal anemia was associated with LBW (PAR range = 7-18%), and fetal anemia was associated with increased IM (PAR not available). We estimate that each year 75,000 to 200,000 infant deaths are associated with malaria infection in pregnancy. The failure to apply known effective antimalarial interventions through antenatal programs continues to contribute substantially to infant deaths globally.
R W Steketee; B L Nahlen; M E Parise; C Menendez
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  64     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-06-26     Completed Date:  2001-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  AIM; IM    
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
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MeSH Terms
Africa / epidemiology
Anemia, Iron-Deficiency / epidemiology,  etiology
Cost of Illness*
Epidemiologic Studies
HIV Infections / epidemiology
Infant Mortality
Infant, Newborn
Malaria / complications,  mortality*,  prevention & control*
Malaria, Falciparum / mortality,  prevention & control
Pregnancy Complications, Hematologic / epidemiology,  etiology
Pregnancy Complications, Parasitic / mortality*,  prevention & control*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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