Document Detail


The burden of faulty proofreading in colon cancer.
MedLine Citation:
PMID:  23358219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants that adversely affect the proofreading function of DNA polymerases encoded by POLE and POLD1.
Authors:
Somasekar Seshagiri
Related Documents :
24529029 - Personal and family history of cancer and the risk of barrett's esophagus in men.
23071479 - A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single lo...
25013169 - A novel reannotation strategy for dissecting dna methylation patterns of human long int...
25074879 - Creation of a diagnostic wait times measurement framework based on evidence and consensus.
23801749 - The cpg island methylator phenotype: what's in a name?
23796299 - Measuring the quality of a childhood cancer care delivery system: assessing stakeholder...
20041869 - Herpes simplex virus type-2 in egyptian patients with bladder cancer or cystitis.
11694279 - Glass fibers covered with sol-gel glass as a new support for affinity chromatography co...
25213829 - Contrast-enhanced dynamic and diffusion-weighted mr imaging at 3.0t to assess aggressiv...
Publication Detail:
Type:  News    
Journal Detail:
Title:  Nature genetics     Volume:  45     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-03-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-2     Citation Subset:  IM    
Affiliation:
Genentech Inc., Department of Molecular Biology, South San Francisco, California, USA. sekar@gene.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Colorectal Neoplasms / genetics*
DNA Mismatch Repair / genetics*
DNA Polymerase II / genetics*
DNA Polymerase III / genetics*
DNA Replication / genetics*
Germ-Line Mutation / genetics
Humans
Models, Biological
Chemical
Reg. No./Substance:
EC 2.7.7.-/DNA Polymerase II; EC 2.7.7.-/DNA Polymerase III; EC 2.7.7.-/POLD1 protein, human; EC 2.7.7.-/POLE protein, human
Comments/Corrections
Erratum In:
Nat Genet. 2013 Oct;45(10):1261

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Loss of function of the new interferon IFN-?4 may confer protection from hepatitis C.
Next Document:  Crocetin administration ameliorates endotoxin-induced disseminated intravascular coagulation in rabb...