Document Detail

The burden of faulty proofreading in colon cancer.
MedLine Citation:
PMID:  23358219     Owner:  NLM     Status:  MEDLINE    
Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants that adversely affect the proofreading function of DNA polymerases encoded by POLE and POLD1.
Somasekar Seshagiri
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Publication Detail:
Type:  News    
Journal Detail:
Title:  Nature genetics     Volume:  45     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-03-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-2     Citation Subset:  IM    
Genentech Inc., Department of Molecular Biology, South San Francisco, California, USA.
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MeSH Terms
Colorectal Neoplasms / genetics*
DNA Mismatch Repair / genetics*
DNA Polymerase II / genetics*
DNA Polymerase III / genetics*
DNA Replication / genetics*
Germ-Line Mutation / genetics
Models, Biological
Reg. No./Substance:
EC 2.7.7.-/DNA Polymerase II; EC 2.7.7.-/DNA Polymerase III; EC 2.7.7.-/POLD1 protein, human; EC 2.7.7.-/POLE protein, human
Erratum In:
Nat Genet. 2013 Oct;45(10):1261

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