Document Detail

The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization.
MedLine Citation:
PMID:  10681427     Owner:  NLM     Status:  MEDLINE    
Ocular neovascularization is the leading cause of blindness in developed countries and often causes rapid loss of vision in age-related macular degeneration. Acute visual loss is most often due to hemorrhage from new vessels that have extended from the choroid into the subretinal space. Growth of abnormal vessels beneath the retina in this condition is known as subretinal neovascularization (SRN). Age-related animal models of macular degeneration and SRN have not been described. Current animal models of SRN depend on chemical or physical stimuli to initiate growth of subretinal vessels. The genes responsible for age-related human macular degeneration with SRN have not been firmly identified. We report an angiogenic phenotype in Bst/+ mice that is age-related, clinically evident, and resembles human SRN. This represents a spontaneous, genetically determined model of SRN. Bst/+ mice offer the possibility of exploring the molecular mechanisms of SRN without the need for exogenous agents.
R S Smith; S W John; A Zabeleta; M T Davisson; N L Hawes; B Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  97     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-11     Completed Date:  2000-04-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2191-5     Citation Subset:  IM    
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
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MeSH Terms
Aging / physiology*
Chromosome Mapping
Disease Models, Animal
Eye / pathology
Fluorescein Angiography
Mice, Inbred C57BL
Retinal Neovascularization / genetics*,  pathology
Grant Support

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