| The bronchial circulation--worth a closer look: a review of the relationship between the bronchial vasculature and airway inflammation. | |
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MedLine Citation:
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PMID: 20025051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Until recently, the bronchial circulation has been relatively ignored in the research and clinical arenas, perhaps because of its small volume and seeming dispensability relative to the pulmonary circulation. Although the bronchial circulation only receives around 1% of the cardiac output in health, it serves functions that are critical to maintaining airway and lung function. The bronchial circulation also plays an important role in many lung and airway diseases; through its ability to increase in size, the bronchial circulation is able to provide lung parenchymal perfusion when the pulmonary circulation is compromised, and more recently the role of the bronchial circulation in the pathogenesis of inflammatory airway disease has been explored. Due to the anatomic variability and small volume of the bronchial circulation, much of the research to date has necessitated the use of animal models and invasive procedures. More recently, non-invasive techniques for measuring bronchial blood flow in the mucosal microvascular network have been developed and offer a new avenue for the study of this circulation in humans. In conjunction with molecular research, measurement of airway blood flow (Q(aw)) may help elucidate the role of the bronchial circulation in inflammatory airway disease and become a useful tool for monitoring therapy. |
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Authors:
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Angela McCullagh; Mark Rosenthal; Adam Wanner; Andres Hurtado; Simon Padley; Andrew Bush |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric pulmonology Volume: 45 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-24 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 1-13 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Remodeling Animals Bronchi / anatomy & histology, blood supply*, physiopathology* Bronchial Arteries / anatomy & histology, physiopathology* Bronchial Diseases / physiopathology Bronchoconstriction Humans Inflammation / physiopathology* Lung Diseases / physiopathology* Neovascularization, Pathologic / physiopathology Pulmonary Circulation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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