Document Detail


The "broken heart syndrome": State of the art.
MedLine Citation:
PMID:  22795894     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Takotsubo cardiomyopathy is a reversible condition, characterized by transient left ventricular systolic dysfunction, that mimics an acute coronary syndrome. It usually occurs after physical or emotional stress, predominantly in postmenopausal women, although it also can affect younger age groups and males. It often presents as chest pain or dyspnea with electrocardiographic changes and mild elevation of cardiac enzymes suggesting acute myocardial infarction. Coronary angiography excludes obstructive coronary disease, and imaging reveals ventricular apical akinesia and compensatory hypercontractility of the basal segments. Various pathophysiological mechanisms have been proposed for the syndrome, such as occult atherosclerotic disease, multivessel spasm and/or microvascular dysfunction. However, the most widely accepted hypothesis at present is an excess of catecholamines causing calcium overload in cardiac myocytes, leading to disruption of contraction and ventricular function. Treatment is essentially supportive, with spontaneous and complete reversal of the changes within days or weeks. However, the presence of complications and comorbidities may predict a more adverse prognosis. As much is still unknown about takotsubo cardiomyopathy and the number of reported cases is growing, we present a literature review.
Authors:
Sofia Nóbrega; Dulce Brito
Related Documents :
22489714 - Assessment of acute coronary syndromes: focus on novel biomarkers.
17725764 - Reverse remodeling with resynchronization in an asymptomatic patient with dilated hypok...
22186754 - Serum and saliva levels of cathepsin l in patients with acute coronary syndrome.
9318274 - Short-term emersion affects cardiac function and regional haemolymph distribution in th...
23972554 - Arrhythmias in patients with acute coronary syndrome in the first 24 hours of hospital...
2082444 - Methodological issues in interpreting trends in monica event rates.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-13
Journal Detail:
Title:  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology     Volume:  -     ISSN:  0870-2551     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710716     Medline TA:  Rev Port Cardiol     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.
Affiliation:
Clínica Universitária de Cardiologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisboa, Portugal.
Vernacular Title:
Miocardiopatia Takotsubo: estado da arte.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5.
Next Document:  Costimulatory activation of murine invariant natural killer T cells by toll-like receptor agonists.