Document Detail


A broad survey of cathepsin K immunoreactivity in human neoplasms.
MedLine Citation:
PMID:  23355199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.
Authors:
Gang Zheng; Guido Martignoni; Cristina Antonescu; Elizabeth Montgomery; Charles Eberhart; George Netto; Janis Taube; William Westra; Jonathan I Epstein; Tamara Lotan; Anirban Maitra; Edward Gabrielson; Michael Torbenson; Christine Iacobuzio-Donahue; Angelo Demarzo; Ie Ming Shih; Peter Illei; T C Wu; Pedram Argani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  139     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-19     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism*,  pathology
Adenoma / metabolism*,  pathology
Carcinoma, Renal Cell / diagnosis,  metabolism
Cathepsin K / metabolism*
Diagnosis, Differential
Female
Granular Cell Tumor / metabolism,  pathology
Histiocytic Disorders, Malignant / metabolism,  pathology
Humans
Immunohistochemistry / methods*
Kidney Neoplasms / diagnosis,  metabolism
Male
Melanoma / metabolism,  pathology
Neoplasms / metabolism*,  pathology
Paraganglioma / metabolism,  pathology
Sarcoma, Alveolar Soft Part / diagnosis,  metabolism
Tissue Array Analysis
Tumor Markers, Biological / metabolism
Grant Support
ID/Acronym/Agency:
P30 CA006973/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 3.4.22.38/Cathepsin K
Comments/Corrections

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