| The broad autism phenotype: findings from an epidemiological survey. | |
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MedLine Citation:
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PMID: 15070545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to determine if relatives of children with autism and less severe pervasive developmental disorders (PDDs) have higher rates of various components of the broad autistic phenotype. Psychiatric and medical disorders were investigated. Parents of children with PDDs were selected from an epidemiological survey and compared with parents of control children with non-autistic developmental problems. Rates of abnormalities and disorders were compared in relatives of 79 cases and 61 controls. Medical and autoimmune disorders in both groups were endorsed by few relatives. Specific developmental disorders were commoner in parents of controls. Depression and anxiety were significantly more prevalent in mothers of children with PDDs. Significantly more PDD children had at least one first-degree relative with anxiety and one second-degree relative with OCD. PDDs were commoner in first-degree relatives. The implications of the findings for the definition of the broad phenotype of autism are discussed. |
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Authors:
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N Micali; S Chakrabarti; E Fombonne |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Autism : the international journal of research and practice Volume: 8 ISSN: 1362-3613 ISO Abbreviation: Autism Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-04-08 Completed Date: 2004-06-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9713494 Medline TA: Autism Country: England |
Other Details:
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Languages: eng Pagination: 21-37 Citation Subset: IM |
Affiliation:
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Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK. N.Micali@iop.kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety Autistic Disorder / complications*, epidemiology, genetics, psychology Autoimmune Diseases Case-Control Studies Child Child Development Disorders, Pervasive / complications*, epidemiology, genetics, psychology Child, Preschool Comorbidity Depression England / epidemiology Epidemiologic Studies Female Humans Incidence Male Parent-Child Relations* Phenotype |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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