Document Detail


The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand.
MedLine Citation:
PMID:  1316239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During Drosophila retinal development, the R8 photo-receptor neuron induces a neighboring cell to assume an R7 cell fate through cell contact. This is mediated by the transmembrane protein bride of sevenless (boss) on the surface of the R8 cell, which binds the sevenless tyrosine kinase receptor (sev) on the surface of the R7 precursor cell. The boss protein, which contains a large extracellular domain, seven transmembrane segments, and a C-terminal cytoplasmic domain, has an exceptional structure for a ligand of a receptor tyrosine kinase. Using a panel of antibodies directed to various cytoplasmic and extracellular epitopes, we demonstrate that the entire boss protein from its extreme N-terminus to its extreme C-terminus is internalized by sev-expressing tissue culture cells and by the R7 precursor cell in the developing eye imaginal disc. The receptor-mediated transfer of a transmembrane ligand represents a novel mechanism for protein transfer between developing cells.
Authors:
R L Cagan; H Krämer; A C Hart; S L Zipursky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  69     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  393-9     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles 90024-1570.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila Proteins*
Drosophila melanogaster / physiology*
Endocytosis
Eye Proteins / chemistry,  immunology,  metabolism*
Ligands
Membrane Glycoproteins / chemistry,  immunology,  metabolism*
Membrane Proteins / chemistry,  immunology,  metabolism*
Microscopy, Electron
Peptide Mapping
Protein Binding
Protein-Tyrosine Kinases / metabolism*
Receptor Protein-Tyrosine Kinases*
Receptors, Cell Surface / physiology*
Receptors, Peptide*
Retina / embryology*
Grant Support
ID/Acronym/Agency:
GM-07104/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Eye Proteins; 0/Ligands; 0/Membrane Glycoproteins; 0/Membrane Proteins; 0/Receptors, Cell Surface; 0/Receptors, Peptide; 0/boss protein, Drosophila; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/sev protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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